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Griseum centrale, a homologue of the periaqueductal gray in the lamprey

机译：中央灰麻七lamp鳗导水管周围灰色的同系物

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摘要

Fear, a response to threatening stimuli and important for survival, is a behavior found throughout the animal kingdom. One critical structure involved in the expression of fear-related behavior is the periaqueductal gray (PAG) in mammals, and in the zebrafish, the griseum centrale. Here, we show in the lamprey, belonging to the oldest now living group of vertebrates, that a bilateral periventricular nucleus in the ventral mesencephalon has a similar location to that of the PAG and griseum centrale . It targets the pretectum and the substantia nigra pars compacta (SNc), expresses the dopamine D1 and D2 receptors and receives input from the pallium (cortex in mammals), hypothalamus, the raphe area and SNc. These are all hallmarks of the mammalian PAG. In addition, like in the zebrafish, there is an input from the interpeduncular nucleus. Our results thus suggest that a structure homologous to the PAG/ griseum centrale was present very early in vertebrate evolution. Graphical abstract Display Omitted Highlights ? A homologue of the mammalian PAG is present in the lamprey. ? As in the zebrafish, this structure is named griseum centrale. ? The neuronal circuitry for fear-related behavior is evolutionarily conserved.
机译：恐惧是对威胁性刺激的一种反应，对生存很重要，是整个动物界普遍存在的一种行为。恐惧相关行为的表达中涉及的一种关键结构是哺乳动物以及斑马鱼中央灰鼠中的导水管周围灰色（PAG）。在这里，我们在属于现存最古老的脊椎动物群的七lamp鳗中显示，腹侧中脑的双侧脑室周围核的位置与PAG和中央灰质的位置相似。它靶向前额和黑质致密部（SNc），表达多巴胺D1和D2受体，并接收来自大脑皮层（哺乳动物的皮质），下丘脑，缝区和SNc的输入。这些都是哺乳动物PAG的标志。另外，像在斑马鱼中一样，有来自椎弓根间核的输入。因此，我们的结果表明，在脊椎动物进化的早期，就存在与PAG /中央灰鼠同源的结构。图形摘要显示省略的突出显示？七lamp鳗中存在哺乳动物PAG的同源物。 ？就像斑马鱼一样，这种结构被称为中央灰麻。 ？恐惧相关行为的神经回路在进化上是保守的。

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