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TonEBP mediates LPS-induced memory loss

机译：TonEBP介导LPS诱发的记忆力减退

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Epigenetic modulation of microglia modulates the pro-inflammatory cytokines expression in vitro Vaccinia-related kinase 2 is critical for microglia-mediated synapse elimination during neurodevelopment During postnatal neurodevelopment, some of the excessively formed synapses need to be trimmed by microglia in order to com- plete the formation of neural circuits in brain. Lack of synaptic regulation by microglia has been implicated in neurodevelop- mental disorders such as autism, schizophrenia, and intellectual disability. Here we suggest that vaccinia-related kinase 2 (VRK2), which is expressed in microglia, supports synaptic elimination activity of microglia. In VRK2-deficeint mice (VRK2KO), reduced number of presynaptic puncta within microglia was observed. Moreover, the number of presynaptic puncta and synapses were abnormally increased in VRK2KO mice at second postnatal week. The difference did not persist in adulthood. Even though an increase in number of synapses was normalized, adult VRK2KO mice showed behavioral defects in social behavior, contextual fear memory, and spatial memory.
机译：小胶质细胞的表观遗传学调控在体外调节促炎性细胞因子的表达痘苗相关激酶2对于神经发育过程中小胶质细胞介导的突触消除非常重要。大脑中神经回路的形成。小胶质细胞缺乏对突触调节的作用，与自闭症，精神分裂症和智力残疾等神经发育疾病有关。在这里，我们建议在小胶质细胞中表达的痘苗相关激酶2（VRK2）支持小胶质细胞的突触消除活性。在VRK2-deficeint小鼠（VRK2KO）中，观察到小胶质细胞内突触前点的数量减少。此外，在出生后第二周，VRK2KO小鼠的突触前突触和突触数量异常增加。这种差异并没有持续到成年期。即使使突触数量增加正常化，成年VRK2KO小鼠在社交行为，上下文恐惧记忆和空间记忆方面仍表现出行为缺陷。

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