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首页> 外文期刊>Immunity Ageing >Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers
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Evidence of accelerated ageing in clinical drug addiction from immune, hepatic and metabolic biomarkers

机译：来自免疫，肝和代谢生物标志物的临床药物成瘾加速衰老的证据

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Background Drug addiction is associated with significant disease and death, but its impact on the ageing process has not been considered. The recent demonstration that many of the items available in routine clinical pathology have applicability as biomarkers of the ageing process implies that routine clinical laboratory parameters would be useful as an initial investigation of this possibility. Methods 12,093 clinical laboratory results 1995–2006 were reviewed. To make the age ranges of the medical and addicted groups comparable the age range was restricted to 15–45 years. Results 739 drug addicted (DA) and 5834 general medical (GM) age matched blood samples were compared. Significant elevation of immune parameters was noted in the C-reactive protein, erythrocyte sedimentation rate, total lymphocyte count, serum globulins and the globulin:albumin ratio (P < 0.01). Alanine aminotranferase, creatinine, urea, and insulin like growth factor-1 were also significantly higher (P < 0.01) in the DA group. Albumin, body mass index and dihydroepiandrosterone sulphate were unchanged and cholesterol was lower (all P < 0.05). Conclusion These data demonstrate for the first time that addiction is associated with an altered profile of common biomarkers of ageing raising the possibility that the ageing process may be altered in this group. Infective and immune processes may be centrally involved. They suggest that addiction forms an interesting model to further examine the contribution of immune suppression and hyperstimulation to the ageing process.
机译：背景药物成瘾与重大疾病和死亡相关，但尚未考虑其对衰老过程的影响。最近的证明表明，常规临床病理学中的许多项目都可以用作衰老过程的生物标志物，这表明常规临床实验室参数将可作为对此可能性的初步研究。方法回顾1995-2006年的12,093例临床实验室结果。为了使医疗和成瘾者的年龄范围可比，年龄限制在15-45岁之间。结果比较了739名成瘾者（DA）和5834名普通医学（GM）年龄匹配的血液样本。 C反应蛋白，红细胞沉降率，总淋巴细胞计数，血清球蛋白和球蛋白与白蛋白之比表明免疫参数显着升高（P <0.01）。在DA组中，丙氨酸氨基转移酶，肌酐，尿素和胰岛素样生长因子-1也显着较高（P <0.01）。白蛋白，体重指数和硫酸二氢表雄酮不变，胆固醇较低（均P <0.05）。结论这些数据首次证明，成瘾与衰老的常见生物标志物谱变化有关，从而增加了该组衰老过程可能改变的可能性。感染和免疫过程可能集中参与。他们认为成瘾形成了一个有趣的模型，可以进一步研究免疫抑制和过度刺激对衰老过程的影响。

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