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首页> 外文期刊>Indian Journal of Critical Care Medicine >The utilization of the surviving sepsis campaign care bundles in the treatment of pediatric patients with severe sepsis or septic shock in a resource-limited environment: A prospective multicenter trial
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The utilization of the surviving sepsis campaign care bundles in the treatment of pediatric patients with severe sepsis or septic shock in a resource-limited environment: A prospective multicenter trial

机译：在资源有限的环境中，尚存的脓毒症运动护理套装在患有严重脓毒症或败血性休克的小儿患者中的应用：一项前瞻性多中心试验

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Background: Sepsis is a common condition affecting the lives of infants and children worldwide. Although implementation of the surviving sepsis campaign (SSC) care bundles was once believed to be effective in reducing sepsis mortality rates, the approach has recently been questioned. Methods: The study was a prospective, interventional, multicenter trial. Infants and children aged 1 month to 15 years in seven different large academic centers in Thailand who had been diagnosed with severe sepsis or septic shock. They were given treatment based on the SSC care bundles. Results: A total of 519 children with severe sepsis or septic shock were enrolled in the study. Among these, 188 were assigned to the intervention group and 331 were recruited to the historical case–control group. There were no significant differences in the baseline clinical characteristics. The intervention group was administered a significantly higher fluid bolus than was the control group (28.3 ± 17.2 cc/kg vs. 17.7 ± 10.6 cc/kg; P = 0.02) with early vasopressor used (1.5 ± 0.7 h) compared to control group (7.4 ± 2.4 h, P 0.05). More importantly, our sepsis mortality reduced significantly from 37% ± 20.7% during the preintervention period to 19.4% ± 14.3% during the postintervention period (P 0.001). Conclusion: Our study demonstrated a significant reduction in sepsis mortality after the implementation of the SSC care bundles. Early diagnosis of the disease, optimum hemodynamic resuscitation, and timely antibiotic administration are the key elements of sepsis management.
机译：背景：败血症是一种普遍的疾病，会影响全世界婴儿和儿童的生活。尽管曾经认为尚存败血症运动（SSC）护理包的实施可以有效降低败血症死亡率，但最近对该方法提出了质疑。方法：该研究是一项前瞻性，干预性，多中心试验。在泰国的七个不同的大型学术中心中，被诊断出患有严重脓毒症或败血性休克的1个月至15岁的婴儿和儿童。根据SSC护理组合对他们进行了治疗。结果：共有519名患有严重败血症或败血性休克的儿童进入研究。其中，有188人被划入干预组，而331人被划入历史病例对照组。基线临床特征无明显差异。与对照组相比，干预组给予了早期血管加压药（1.5±0.7 h），比对照组（28.3±17.2 cc / kg vs. 17.7±10.6 cc / kg; P = 0.02）显着更高的液体推注（ 7.4±2.4小时，P ＜0.05）。更重要的是，我们的败血症死亡率从干预前的37％±20.7％显着降低到干预后的19.4％±14.3％（P <0.001）。结论：我们的研究表明，实施SSC护理包后，败血症死亡率显着降低。疾病的早​​期诊断，最佳的血流动力学复苏以及及时的抗生素管理是败血症管理的关键要素。

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