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Reconsidering low-dose aspirin therapy for cardiovascular disease: a study protocol for physician and patient behavioral change

机译:重新考虑小剂量阿司匹林治疗心血管疾病:医师和患者行为改变的研究方案

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Background There are often disparities between current evidence and current practice. Decreasing the gap between desired practice outcomes and observed practice outcomes in the healthcare system is not always easy. Stopping previously recommended or variably recommended interventions may be even harder to achieve than increasing the use of a desired but under-performed activity. For over a decade, aspirin has been prescribed for primary prevention of cardiovascular disease and for patients with the coronary artery disease risk equivalents; yet, there is no substantial evidence of an appropriate risk-benefit ratio to support this practice. This paper describes the protocol of a randomized trial being conducted in six primary care practices in the Denver metropolitan area to examine the effectiveness of three interventional strategies to change physician behavior regarding prescription of low-dose aspirin. Methods All practices received academic detailing, one arm received clinician reminders to reconsider aspirin, a second arm received both clinician and patient messages to reconsider aspirin. The intervention will run for 15 to 18 months. Data collected at baseline and for outcomes from an electronic health record will be used to assess pre- and post-interventional prescribing, as well as to explore any inappropriate decrease in aspirin use by patients with known cardiovascular disease. Discussion This study was designed to investigate effective methods of changing physician behavior to decrease the use of aspirin for primary cardiovascular disease prevention. The results of this study will contribute to the small pool of knowledge currently available on the topic of ceasing previously supported practices. Trial Registration ClinicalTrials.gov: NCT01247454
机译:背景技术当前的证据与当前的实践之间常常存在差异。缩小医疗体系中期望的实践结果与观察到的实践结果之间的差距并不总是那么容易。停止先前建议的或可变建议的干预措施可能比增加对期望的但绩效不佳的活动的使用甚至更难实现。十多年来,阿司匹林已被处方用于心血管疾病的一级预防,以及具有冠心病风险的患者。但是,没有足够的证据证明合适的风险收益率可以支持这种做法。本文介绍了在丹佛大都会地区的六种初级保健实践中进行的一项随机试验的规程,以检查三种干预策略改变低剂量阿司匹林处方对医生行为的有效性。方法所有实践均接受了详细的学术研究,其中一只手收到了临床医生关于重新考虑阿司匹林的提醒,另一只手收到了临床医生和患者的信息来重新考虑阿司匹林。干预将持续15到18个月。在基线时收集的数据以及用于从电子健康记录中获取结果的数据将用于评估干预前后的处方,并探讨已知心血管疾病患者使用阿司匹林的任何不当减少。讨论本研究旨在研究改变医师行为以减少使用阿司匹林预防心血管疾病的有效方法。这项研究的结果将有助于减少目前关于停止先前支持的实践的知识。试验注册ClinicalTrials.gov:NCT01247454

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