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首页> 外文期刊>Indian journal of nephrology >Non-diabetic renal disease in type 2 diabetes mellitus: Study of renal - retinal relationship
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Non-diabetic renal disease in type 2 diabetes mellitus: Study of renal - retinal relationship

机译：2型糖尿病的非糖尿病性肾脏疾病：肾-视网膜关系的研究

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Diabetic nephropathy (DN) has become the leading cause of end-stage renal disease worldwide. Non-diabetic renal disease (NDRD), is known to occur in diabetic patients. The renal and retinal relationship in type 2 diabetes mellitus (T2DM) with nephropathy is not uniform. This study was carried to study the histological spectrum of nephropathy in type 2 diabetic patients with proteinuria and its relationship with diabetic retinopathy (DR). Total 31 (males - 26; females - 5) proteinuric type 2 diabetic patients were studied. Average age of patients was 50.7 years. Nephrotic syndrome was noted in 21 (67.7%) patients. Overall, isolated DN, NDRD and NDRD superimposed on DN (mixed lesion) were observed in 12 (38.7%), 13 (41.9%) and 6 (19.4%) cases, respectively. DR was absent in 21/31 (67.7%) cases. The spectrum of nephropathy in patients without DR included: DN in 6 (28.57%), NDRD in 12 (57.14%) and mixed lesion in 3 (14.29%). Kidney histology in patients with DR (n-10) revealed DN in 6 (60%), NDRD in 1 (10%) and mixed lesion in 3 (30%) patients. Thus, absence of DR favors NDRD but does not exclude DN because isolated DN was noted in 28.57% cases in absence of DR. Similarly biopsy proven NDRD (pure NDRD; 10% and mixed lesion; 30%) was noted in 40% of cases in presence of DR. In summary, patients with T2DM had higher incidence of NDRD. DR is less frequent (32.3%) in type 2 diabetes and is a poor predictor of type of nephropathy. Hence, renal biopsy is essential for precise diagnosis of nephropathy in patients with T2DM.Keywords: Diabetic retinopathy, nephrotic syndrome, non-diabetic renal disease, type 2 diabetes mellitus
机译：糖尿病肾病（DN）已成为世界范围内终末期肾脏疾病的主要原因。已知非糖尿病肾病（NDRD）发生在糖尿病患者中。 2型糖尿病（T2DM）与肾病的肾和视网膜关系不统一。本研究旨在研究2型糖尿病蛋白尿患者肾病的组织学谱及其与糖尿病视网膜病变（DR）的关系。研究了总共31位（男性-26位;女性-5位）蛋白尿2型糖尿病患者。患者的平均年龄为50.7岁。在21名（67.7％）患者中发现了肾病综合征。总体而言，分别在12例（38.7％），13例（41.9％）和6例（19.4％）的病例中观察到了DN，混合病灶的DN，NDRD和NDRD。 21/31（67.7％）病例不存在DR。没有DR的患者的肾病范围包括：DN 6例（28.57％），NDRD 12例（57.14％），混合病变3例（14.29％）。患有DR（n-10）的患者的肾脏组织学显示，DN（6）（60％），NDRD（1（10％））和混合病变（3（30％））患者。因此，不存在DR有利于NDRD，但不排除DN，因为在没有DR的28.57％的病例中发现了孤立的DN。类似的活检证实为NDRD（纯NDRD; 10％混合病变; 30％），在存在DR的病例中占40％。总之，T2DM患者的NDRD发生率较高。在2型糖尿病中，DR的发生率较低（32.3％），并且对于肾病类型的预测较差。因此，对于2型糖尿病患者，肾活检对于准确诊断肾病必不可少。关键词：糖尿病性视网膜病，肾病综合征，非糖尿病性肾病，2型糖尿病

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