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首页> 外文期刊>Indian Journal of Nuclear Medicine >Quantitative analysis of SPECT imaging parameters in patients with resting perfusion defects on myocardial perfusion scintigraphy
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Quantitative analysis of SPECT imaging parameters in patients with resting perfusion defects on myocardial perfusion scintigraphy

机译：心肌灌注显像对静息灌注缺陷患者SPECT成像参数的定量分析

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Background:Functional status/contractile behaviour of hibernating myocardium was analyzed objectively by analyzing the available quantitative parameters obtained on gated SPECT myocardial perfusion imaging (MPI) using Emory cardiac toolbox (ECTB) software.Materials and Methods:In this retrospective study, 70 patients with perfusion defects on 99Tc-Sestamibi MPI (12 females, 58 males) who also underwent 18F-FDG Cardiac PET study for assessment of hibernating myocardium were included for analysis. Patients were divided in three categories based on summed rest score (SRS) obtained from ECTB software, depicting the extent of perfusion defects. In a study population matched for extent of perfusion defects, quantitative parameters obtained from ECTB software such as left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (EDV), left ventricular end systolic volume (ESV) and left ventricular stroke volume (SV) were compared between patients showing evidence of hibernating myocardium and patients showing no evidence of hibernating myocardium. Student ‘t’ test was applied on the given observations and a P-value <0.05 was considered as a significant difference between the means in two categories.Results:There was no significant difference in LVEF, EDV, ESV and SV measurements between those who demonstrate hibernating myocardium and those who show no evidence of hibernating myocardium across all the categories of patients. Few trends were evident in the present study in LVEF, EDV and ESV measurements i.e., fall in mean LVEF with increasing SRS and rise in mean EDV and ESV with increasing SRS.Conclusions:The findings were consistent with the nature of hibernating myocardium i.e., non-contractile and dysfunctional. The fall in the LVEF was suggestive of deteriorating myocardial function with increasing extent of perfusion defects. The increasing left ventricular EDV and ESV with increasing extent of perfusion defects was suggestive of rising incidence of gross morphological LV cavity dilatation or “Dilated ischemic cardiomyopathy” in these patients.
机译：背景：通过使用Emory心脏工具箱（ECTB）软件分析门控SPECT心肌灌注显像（MPI）上可获得的定量参数，客观地分析了冬眠心肌的功能状态/收缩行为。材料与方法：在这项回顾性研究中，有70例患有糖尿病的患者包括99Tc-Sestamibi MPI（12位女性，58位男性）的灌注缺陷，这些患者也接受了18F-FDG心脏PET研究以评估冬眠心肌的情况。根据从ECTB软件获得的总休息分数（SRS）将患者分为三类，描述了灌注缺陷的程度。在符合灌注缺陷程度的研究人群中，从ECTB软件获得的定量参数，例如左心室射血分数（LVEF），左心室舒张末期容积（EDV），左心室末末收缩期容积（ESV）和左心室搏动量（在显示心肌冬眠证据的患者和未显示心肌冬眠证据的患者之间进行了SV）比较。在给定的观察值上进行了学生't'检验，P值<0.05被认为是两类均值之间的显着差异。结果：LVEF，EDV，ESV和SV测量值之间的差异无统计学意义表现出冬眠的心肌，而没有证据表明在所有类型的患者中都有冬眠的证据。在本研究中，LVEF，EDV和ESV测量的趋势很少，即随着SRS的增加平均LVEF下降，随着SRS的增加平均EDV和ESV上升。结论：研究结果与冬眠心肌的性质一致，即无心肌梗死-收缩和功能障碍。 LVEF的下降提示心肌功能恶化，灌注缺陷程度增加。左心室EDV和ESV随血流灌注缺陷程度的增加而增加，提示这些患者总体形态学上的左心室腔扩张或“扩张型缺血性心肌病”的发生率增加。

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