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首页> 外文期刊>Indian Journal of Pathology and Microbiology >Migration and maturation pattern of fetal enteric ganglia: A study of 16 cases
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Migration and maturation pattern of fetal enteric ganglia: A study of 16 cases

机译：胎儿肠神经节的迁移和成熟方式：16例研究

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Aims: To study the migration and developmental pattern of ganglion cells in fetuses aged 9-21 weeks, and to document whether the migration was occurring circumferentially equally in the entire axis or if there were discrepancies in different portions at the same level. Settings and Design: The hypothesis regarding the pathogenesis of Hirschsprung's disease mainly revolves around two schools. One is the single gradient migration of ganglia and the other is a dual gradient migration theory. Understanding the embryological development of enteric ganglia is necessary to study the pathogenesis of intestinal innervation disorders. Materials and Methods: We studied the development of intestinal ganglia in fetuses aged 9-21 weeks. Serial longitudinal sections from the colon were studied, the first one including the squamo-columnar junction, for the presence and the nature of ganglion cells with Hematoxylin and Eosin, and neurone-specific enolase immunostaining. Transverse sections from proximal gut were studied in a similar fashion. Thus, we evaluated the migration pattern as well as the nature of ganglia in the fetuses. We also measured the length of distal aganglionic segment in these growing fetuses. Results: We noted that ganglion cells appear first in the myenteric plexus followed by deep and superficial submucous plexus. We also found evidences in favor of dual migration theory, and the distal aganglionic segment varies around the circumference of the rectal wall. Conclusions: We got evidences in support of a dual migration pattern of intestinal ganglion cells. The level of distal aganglionic segments when measured from squamo-columnar junction varied with the age of gestation and the length was incongruous. The description of distal aganglionic segment may help surgeons while taking biopsies or during operative procedures.
机译：目的：研究神经节细胞在9-21周龄的胎儿中的迁移和发育模式，并记录迁移在整个轴上是否沿周向均等发生，或者在同一水平的不同部位是否存在差异。设置与设计：关于Hirschsprung病发病机理的假说主要围绕两个流派。一种是神经节的单梯度迁移，另一种是双梯度迁移理论。了解肠道神经节的胚胎发育对于研究肠道神经支配失调的发病机制是必要的。材料和方法：我们研究了9-21周龄胎儿肠道神经节的发育。研究了来自结肠的连续纵切面，第一个包括鳞状-柱状交界处，以了解苏木精和曙红的神经节细胞的存在和性质，以及神经元特异性烯醇化酶免疫染色。以类似的方式研究了近端肠的横切面。因此，我们评估了胎儿的迁移模式以及神经节的性质。我们还测量了这些正在生长的胎儿中远端神经节节段的长度。结果：我们注意到神经节细胞首先出现在肌层神经丛中，然后出现在深层和浅层粘膜下神经丛中。我们还发现了支持双重迁移理论的证据，并且远端神经节节段在直肠壁的周围变化。结论：我们有证据支持肠神经节细胞的双重迁移模式。从鳞状-柱状交界处测量时，远端神经节节段的水平随妊娠年龄而变化，且长度不一致。远端神经节节段的描述可能有助于外科医生在进行活检或手术过程中。

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