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首页> 外文期刊>Insights into Imaging >Pre-operative apparent diffusion coefficient values and tumour region volumes as prognostic biomarkers in glioblastoma: correlation and progression-free survival analyses
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Pre-operative apparent diffusion coefficient values and tumour region volumes as prognostic biomarkers in glioblastoma: correlation and progression-free survival analyses

机译：术前表观扩散系数值和肿瘤区域体积作为胶质母细胞瘤的预后生物标志物：相关性和无进展生存分析

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Objectives Glioblastoma (GB) contains diverse histologic regions. Apparent diffusion coefficient (ADC) values are surrogates for the degree of number of cells within the tumour regions. Because an assessment of ADC values and volumes within tumour sub-compartments of GB is missing in the literature, we aimed to evaluate these associations. Methods A retrospective cohort of 48 patients with GB underwent segmentation to calculate tumour region volumes (in cubic centimetre) and ADC values in tumour regions: normal tissue, enhancing tumour, proximal oedema, distal oedema, and necrosis. Correlation, Kaplan-Meier, and Cox hazard regression analyses were performed. Results We found a statistically significant difference among ADC values for tumour regions: F (4, 220)?=?166.71 and p ?≤?.001 and tumour region volumes (necrosis, enhancing tumour, peritumoural oedema): F (2, 141)?=?136.3 and p ?≤?.001. Post hoc comparisons indicated that the only significantly different mean score was the peritumoural volume in oedema region ( p ?&?.001). We observed a positive significant correlation between ADC of distal oedema and peritumoural volume, r ?=?.418, df?=?34, and p ?=?.011. Cox proportional hazards regression analysis considering only tumour region volumes provided an almost significant model: ??2 log-likelihood?=?146.066, χ ~(2) (4)?=?9.303, and p ?=?.054 with a trend towards significance of the hazard function: p ?=?.067 and HR?=?1.077 for the non-enhancing tumour volume. Conclusions ADC values together with volumes of oedema region might have a role as predictors of progression-free survival (PFS) in patients with GB; we recommend a routine MRI assessment with the calculation of these biomarkers in GB.
机译：目的胶质母细胞瘤（GB）包含不同的组织学区域。表观扩散系数（ADC）值代表肿瘤区域内细胞数量的程度。因为文献中缺少对GB肿瘤亚室中ADC值和体积的评估，所以我们旨在评估这些关联。方法回顾性分析48例GB患者，进行分割以计算肿瘤区域的体积（立方厘米）和肿瘤区域的ADC值：正常组织，增强肿瘤，近端水肿，远端水肿和坏死。进行了相关性，Kaplan-Meier和Cox风险回归分析。结果我们发现肿瘤区域的ADC值之间的统计差异显着：F（4，220）？=？166.71和p？≤？.001，以及肿瘤区域的体积（坏死，增强肿瘤，肿瘤周围水肿）：F（2，141 ）＝ 136.3，p≤0.001。事后比较表明，唯一显着不同的平均得分是水肿区的肿瘤周围体积（p≤0.001）。我们观察到远端水肿的ADC与肿瘤周体积之间呈正显着正相关，r≥0.418，df≥34，p≥0.0111。仅考虑肿瘤区域体积的Cox比例风险回归分析提供了几乎有效的模型：？2对数似然率== 146.066，χ〜（2）（4）？=？9.303，p？= ?. 054，具有趋势对于危险功能的重要性：对于非增强型肿瘤体积，p≥0.9067，HR≥1.077。结论ADC值和水肿区域的体积可能是GB患者无进展生存（PFS）的预测指标。我们建议您进行常规MRI评估，并以GB为单位计算这些生物标记物。

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