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首页> 外文期刊>International Archives of Otorhinolaryngology >HMGB1 in the Pathogenesis of Nasal Inflammatory Diseases and its Inhibition as New Therapeutic Approach: A Review from the Literature
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HMGB1 in the Pathogenesis of Nasal Inflammatory Diseases and its Inhibition as New Therapeutic Approach: A Review from the Literature

机译：HMGB1在鼻炎疾病发病机理中的作用及其作为新治疗方法的抑制作用：文献综述

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Introduction This study is a systematic review on recent developments about the importance of HMGB1 protein in the pathogenesis of rhino-sinusal inflammatory diseases. We also report data on the use of 18-β-glycyrrhetic acid (GA), which has been shown able to inhibit the pro-inflammatory activities of HMGB1, in young patients affected by allergic rhinitis and complaining of nasal obstruction as main symptom. Objectives The objective of this study was to review the literature to demonstrate the importance of HMGB1 in the pathogenesis of nasal inflammatory disorders and understand whether the inhibition of this protein may be an efficacious and innovative therapeutic strategy for patients with rhino-sinusal inflammation. Data Synthesis Authors searched for pertinent articles indexed in PubMed, Scopus, and other health journals between 2004 and 2015. In total, the authors gathered 258 articles: 219 articles through Pubmed and 39 articles from other search engines. The search terms used were as follows: HMGB1 AND “respiratory epithelium,” “airway inflammation,” “rhinitis,” “allergic rhinitis,” “rhinosinusitis,” “nasal polyposis,” “glycyrrhetic acid,” “children.” Conclusions Patients with severe symptoms have the highest serum levels and the highest extracellular expression of HMGB1. GA inhibits HMGB1 chemotactic and mitogenic function by a scavenger mechanism on extracellular HMGB1 accumulation stimulated by lipopolysaccharides in vitro. Treatment of allergic rhinitis with GA is not associated with local or systemic side effects in children and adults.
机译：引言这项研究是关于HMGB1蛋白在鼻-鼻窦炎性疾病发病机制中重要性的最新进展的系统综述。我们还报告了有关18-β-甘草次酸（GA）的使用的数据，该物质已被证明能够抑制HMGB1的促炎活性，用于受变应性鼻炎和以鼻阻塞为主要症状的年轻患者。目的这项研究的目的是回顾文献，以证明HMGB1在鼻炎性疾病的发病机理中的重要性，并了解抑制该蛋白是否对于鼻窦炎患者是一种有效且创新的治疗策略。数据综合作者搜索了2004年至2015年间在PubMed，Scopus和其他健康期刊上索引的相关文章。作者总共收集了258条文章：Pubmed的219条和其他搜索引擎的39条。使用的搜索词如下：HMGB1和“呼吸道上皮”，“气道炎症”，“鼻炎”，“过敏性鼻炎”，“鼻窦炎”，“鼻息肉”，“甘草酸”，“儿童”。结论重症患者血清HMGB1水平最高，胞外表达最高。 GA通过清除剂在体外抑制脂多糖刺激的细胞外HMGB1积累，从而抑制HMGB1趋化和有丝分裂功能。 GA过敏性鼻炎的治疗与儿童和成人的局部或全身性副作用无关。

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