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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Experimental antibacterial activity of selective cyclooxygenase antagonist
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Experimental antibacterial activity of selective cyclooxygenase antagonist

机译：选择性环氧合酶拮抗剂的实验抗菌活性

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Background: From the history of the development of pharmaceutical compounds it is evident that any drug may have the possibility of possessing diverse functions and thus may have useful activity in completely different fields of medicine and different studies showed that newer antimicrobials have revealed antimicrobial action involved in the management of diseases of non-infectious etiology. This study was done to determine in vitro antibacterial activity of selected selective cyclooxygenase-2 inhibitor. Methods: Twenty two strains of gram positive and gram negative bacteria, which were isolated from skin and urinary tract infected patient. These bacteria were being cultured on specific optimal growth media. The antibacterial activity of selective COX-2 (meloxicam, celecoxib, valdecoxib and nimesulide). Inhibitors determined by measuring zone of inhibition and minimal inhibitory concentration (MIC). Results: Results showed that MIC of celecoxib and meloxicam in μg/ml was ranged from 5-80μg/ml on selected bacteria compared with negative control distilled water (D.W) ,valdecoxib was 80-160μg/ml, while and nimesulide was ranged from 5-40 μg/ml .All the selected bacteria were showed sensitivity for all coxib used in this experimental study except Pseudomonas aeruginosa which showed resistant to meloxicam and valdecoxib, Klebsiella pneumoniae resist to nimesulide while Staphylococcus aureus was resist to valdecoxib. The smaller zone of inhibition showed by valdecoxib and celecoxib which was 3mm against Klebsiella pneumoniae, while the larger zone of inhibition showed by nimesulide which was 26mm against Escherichia coli. Conclusions: In conclusion selective cyclooxygenase (cox-2) inhibitor possesses antibacterial activity this is especially for nimesulide and little by valdecoxib. Escherichia coli are sensitive bacteria to all coxib. Consequently; coxib may be regarded as anti-inflammatory and antibacterial agent especially for urinary tract infection where Escherichia coli are the major causative organism.
机译：背景：从药物化合物的发展历史来看，很明显，任何药物都可能具有多种功能，因此可能在完全不同的医学领域中具有有用的活性，并且不同的研究表明，更新的抗菌剂已揭示了与之相关的抗菌作用。非传染性病因疾病的管理。进行这项研究是为了确定所选的选择性环氧合酶2抑制剂的体外抗菌活性。方法：从皮肤和尿路感染患者中分离出22株革兰氏阳性和革兰氏阴性细菌。这些细菌在特定的最佳生长培养基上培养。选择性COX-2（美洛昔康，塞来昔布，伐地昔布和尼美舒利）的抗菌活性。通过测量抑制区和最小抑制浓度（MIC）确定抑制剂。结果：结果显示，与阴性对照蒸馏水（DW）相比，塞来昔布和美洛昔康的MIC（微克/毫升）范围为5-80μg/ ml，缬地昔布为80-160μg/ ml，而尼美舒利的范围为5 -40μg/ ml。除对铜绿假单胞菌显示对美洛昔康和伐地昔布具有抗性的铜绿假单胞菌，对肺炎克雷伯菌对尼美舒利具有抗性，对金黄色葡萄球菌对伐地昔布具有抗性以外，所有选定的细菌均对所有考昔布表现出敏感性。伐地考昔和塞来昔布对肺炎克雷伯菌的抑制作用较小，为3mm;尼美舒利对大肠埃希菌的抑制作用为26mm。结论：总而言之，选择性环加氧酶（cox-2）抑制剂具有抗菌活性，尤其是对尼美舒利具有抑制作用，而伐地昔布则很少。大肠杆菌是对所有coxib敏感的细菌。所以;考昔布可被视为抗炎和抗菌剂，尤其是对于以大肠杆菌为主要病原体的泌尿道感染。

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