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首页> 外文期刊>International Journal of Basic and Applied Sciences >Naphthoquinone impairs reproductive functions in plasmodium berghei berghei-infected male swiss mice
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Naphthoquinone impairs reproductive functions in plasmodium berghei berghei-infected male swiss mice

机译：萘醌损害伯氏疟原虫感染的伯氏瑞士雄性小鼠的生殖功能

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Background: Various antimalarial drugs adversely affect male reproductive functions. Naphtoquinones, a class of antimalarial drugs have been shown to effectively combat malaria parasites. However, the effects of naphtoquinone on reproductive functions remain elusive. The study determined the effects of naphthoquinone on reproductive functions of Plasmodium berghei berghei-infected male Swiss mice Methods: Thirty male Swiss mice were divided into 6 groups (n = 5) namely; Control, 1 mg/kg naphthoquinone, 2 mg/kg naphthoquinone, Plasmodium berghei berghei (Pbb)-infected, Pbb-infected+1 mg/kg naphthoquinone and Pbb-infected+2 mg/kg naphthoquinone. Parasitaemia was confirmed by microscopy. Naphthoquinone (i.p.) was administered for seven days following confirmation of parasitaemia. Thereafter, they were sacrificed. Serum levels of FSH, LH, testosterone and cortisol were assayed via ELISA. Sperm characteristics were evaluated by microscopy. Data were expressed as mean ± SEM and analysed using ANOVA at p0.05. Results: Sperm motility reduced in the Pbb-infected compared with control. Sperm viability, motility and count reduced in naphthoquinone only groups and Pbb-infected+naphthoquinone groups compared with the control. Naphthoquinone groups and Pbb-infected alone decreased in LH and testosterone concentrations compared with the control. Conclusion: Naphthoquinone treatment impaired reproductive functions in Plasmodium berghei berghei-infected male Swiss mice.
机译：背景：各种抗疟药会对男性生殖功能产生不利影响。萘醌是一类抗疟疾药物，已显示可有效对抗疟原虫。但是，萘醌对生殖功能的影响仍然难以捉摸。该研究确定了萘醌对伯氏疟原虫感染的瑞士雄性小鼠生殖功能的影响。方法：将三十只瑞士雄性小鼠分为6组（n = 5）;即，每组30只。对照：1 mg / kg萘醌，2 mg / kg萘醌，伯氏疟原虫（Pbb）感染，Pbb感染的+1 mg / kg萘醌和Pbb感染的+2 mg / kg的萘醌。寄生虫血症通过显微镜确认。确认寄生虫血症后，给予萘醌（腹膜内）治疗7天。此后，他们被处死。通过ELISA测定血清FSH，LH，睾丸激素和皮质醇水平。通过显微镜评估精子特征。数据表示为平均值±SEM，并使用ANOVA在p <0.05下进行分析。结果：与对照相比，Pbb感染的精子活力降低。与对照组相比，仅萘醌组和Pbb感染+萘醌组的精子活力，活力和计数降低。与对照组相比，单独使用萘醌组和Pbb感染的LH和睾丸激素浓度降低。结论：萘醌治疗损害了伯氏疟原虫感染的雄性瑞士小鼠的生殖功能。

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