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首页> 外文期刊>International Journal of Biochemistry Research & Review >Interleukin 10 Gene Polymorphisms and Susceptibility to Nephropathy in Egyptian Diabetic Patients
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Interleukin 10 Gene Polymorphisms and Susceptibility to Nephropathy in Egyptian Diabetic Patients

机译：白细胞介素10基因多态性与埃及糖尿病患者肾病的易感性

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Background: Type 2 diabetes mellitus (T2DM) is recognized as one of the most common causes of end-stage renal disease. In T2DM patients, a certain cytokine genotype is associated with an increased susceptibility to diabetic nephropathy. Aim: In this study we clarify the relation between IL-10 gene polymorphisms at position (-592 A/C) and its plasma levels in T2D Egyptian patients with and without nephropathy. Methods: 80 subjects were enrolled in this study, 30 diabetic patients without nephropathy, 30 DN patients and 20 healthy control subjects. For all subjects, kidney function tests, FBG, HbA1c, estimation of micro-albuminuria, plasma IL-10 level and IL-10 gene polymorphism were done. Results and Conclusions: Diabetic patients with and without nephropathy exhibited significantly higher FBG, HbA1c than healthy subjects. Creatinine levels were increased in DN patients compared to both diabetic without nephropathy and healthy subjects. There is significant increase in micro-albuminuria levels in DN patients compared to diabetic without nephropathy and healthy control subjects. There is significant increase in IL-10 levels in DN patients compared to diabetic without nephropathy and healthy control subjects. The IL-10-(592) CC genotype associated with an increased risk of type 2 DM and the C allele was significantly associated with an increased risk of type 2 DM, there are no significant differences between the two T2D patient groups as regard IL-10 gene polymorphism.
机译：背景：2型糖尿病（T2DM）被认为是终末期肾脏疾病的最常见原因之一。在T2DM患者中，某种细胞因子基因型与糖尿病性肾病的易感性增加有关。目的：在这项研究中，我们阐明了有或没有肾病的埃及T2D患者中IL-10基因多态性（-592 A / C）与血浆水平之间的关系。方法：本研究共纳入80名受试者，30名无肾病的糖尿病患者，30名DN患者和20名健康对照受试者。对于所有受试者，均进行了肾功能检查，FBG，HbA1c，微蛋白尿评估，血浆IL-10水平和IL-10基因多态性。结果与结论：患有和不患有肾病的糖尿病患者的FBG，HbA1c明显高于健康受试者。与没有肾病的糖尿病患者和健康受试者相比，DN患者的肌酐水平升高。与没有肾病的糖尿病患者和健康对照组相比，DN患者的微量白蛋白尿水平显着增加。与没有肾病的糖尿病患者和健康对照组相比，DN患者的IL-10水平显着增加。 IL-10-（592）CC基因型与2型DM风险增加相关，而C等位基因与2型DM风险增加显着相关，在两个T2D患者组之间，关于IL- 10个基因多态性。

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