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首页> 外文期刊>International Journal of Breast Cancer >C-Reactive Protein and Breast Cancer: New Insights from Old Molecule
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C-Reactive Protein and Breast Cancer: New Insights from Old Molecule

机译：C反应蛋白与乳腺癌：旧分子的新见解

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摘要

Recently an association between breast cancer and inflammation has emerged as the seventh hallmark of cancer. Chronic inflammation is a key contributor in the development and progression of carcinogenesis. Inflammatory pathways play an important role in the causation of breast cancer. C-reactive protein (CRP) an acute-phase reactant inflammatory protein is synthesized in hepatocytes in response to cytokines that are released from leucocytes within the tumor microenvironment. Several epidemiological studies appraised an association of CRP with breast cancer risk with inconsistent findings. Elevated levels at the time of diagnosis of breast cancer indicate aggressiveness of the tumor. CRP is also a well-established independent prognostic marker. Breast cancer survivors with the state of chronic inflammation are at risk of recurrence and metabolic disturbances. CRP lowering agents along with chemotherapeutic drugs will improve the survival of breast cancer patients. Also, it is a risk predictor for subsequent cardiotoxicity in patients receiving chemotherapy. The present review is aimed at elucidating the role of C-reactive protein, as an inflammatory risk marker and prognostic predictor of breast cancer. It also focuses on conflicting views on the role of CRP in breast cancer and its impact on therapeutic interventions.
机译：最近，乳腺癌和炎症之间的联系已经成为癌症的第七个标志。慢性炎症是癌发生发展和进展的关键因素。炎性途径在乳腺癌的病因中起重要作用。 C反应蛋白（CRP）是一种急性期反应性炎症蛋白，响应于肿瘤微环境中白细胞释放的细胞因子而在肝细胞中合成。几项流行病学研究评估了CRP与乳腺癌风险之间的关联，但结果不一致。诊断乳腺癌时水平升高表明肿瘤的侵袭性。 CRP也是公认的独立预后指标。处于慢性炎症状态的乳腺癌幸存者有复发和代谢紊乱的风险。降低CRP的药物以及化学治疗药物将提高乳腺癌患者的生存率。而且，它是接受化疗的患者随后发生心脏毒性的危险指标。本综述旨在阐明C反应蛋白作为乳腺癌的炎症危险标志物和预后指标的作用。它还集中在对CRP在乳腺癌中的作用及其对治疗干预的影响的观点存在分歧。

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