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首页> 外文期刊>International Journal of Breast Cancer >Risk Factors for Premenopausal Breast Cancer in Bangladesh
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Risk Factors for Premenopausal Breast Cancer in Bangladesh

机译：孟加拉国绝经前乳腺癌的危险因素

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Background. The incidence of premenopausal breast cancer is rising throughout South Asia. Our objective was to determine the role of risk factors associated with Westernization for premenopausal breast cancer in Bangladesh.Methods. We conducted a matched case-control study between January 1, 2007, and December 31, 2010, at four hospitals in Bangladesh. Cases were premenopausal women diagnosed with invasive breast cancer. Controls were premenopausal women with no personal history of breast cancer. Logistic regression was used to calculate the odds ratios (OR) for breast cancer.Results. We identified 129 age-matched pairs. The mean age of breast cancer diagnosis was 37.5 years. Each year decrease in the age of menarche significantly increased the risk of breast cancer (OR = 1.67, 95% CI 1.09–2.56,P=0.02). The risk was also increased with a current body mass index of ≥25 kg/m2(OR = 5.24, 95% CI 1.10–24.9,P=0.04). Age at first childbirth, parity, and breastfeeding were not significantly associated with premenopausal breast cancer risk (P>0.05).Conclusions. Age at menarche and adult weight gain were associated with premenopausal breast cancer risk. Other factors associated with Westernization may not be relevant to premenopausal breast cancer risk in Bangladesh.
机译：背景。在整个南亚，绝经前乳腺癌的发病率正在上升。我们的目标是确定与Westernization相关的危险因素在孟加拉国绝经前乳腺癌中的作用。我们在2007年1月1日至2010年12月31日之间对孟加拉国的四家医院进行了匹配的病例对照研究。病例是被诊断为浸润性乳腺癌的绝经前妇女。对照是绝经前的女性，没有乳腺癌的个人病史。使用Logistic回归计算乳腺癌的优势比（OR）。我们确定了129个年龄匹配的配对。乳腺癌诊断的平均年龄为37.5岁。每年初潮年龄的减少都会显着增加患乳腺癌的风险（OR = 1.67，95％CI 1.09–2.56，P = 0.02）。当前体重指数≥25kg / m2（OR = 5.24，95％CI 1.10-24.9，P = 0.04），风险也会增加。初生年龄，胎次和母乳喂养与绝经前乳腺癌风险没有显着相关性（P> 0.05）。初潮年龄和成人体重增加与绝经前乳腺癌风险有关。与西方化相关的其他因素可能与孟加拉国绝经前的乳腺癌风险无关。

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