• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Breast Cancer >Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer
【24h】

Pretreatment Thrombocytosis as a Prognostic Factor in Metastatic Breast Cancer

机译：预处理血小板增多症是转移性乳腺癌的预后因素

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background. An elevated platelet count is often associated with malignancies, and it has been confirmed as an adverse prognostic factor in various cancers including early stage breast cancer. We sought to determine if thrombocytosis is also a prognostic factor in metastatic breast cancer.Patients and Methods. The records of 165 metastatic breast cancer patients with complete follow-up that had thrombocytosis or normal platelet counts were reviewed. Kaplan-Meier curves were constructed, and the survivals of the two groups were compared using the LogRank test. A Cox regression analysis was used to determine if thrombocytosis is an independent factor for overall and progression free survival.Results. There was a statistically significant difference in overall and progression free survival favoring the normal platelets group (LogRank testP=0.038and 0.008, resp.). Thrombocytosis remained a significant adverse prognostic factor in multivariate analysis. Other independent prognostic factors for overall survival included age, ER/PR status, and grade.Conclusion. Thrombocytosis represents an independent adverse prognostic factor in patients with metastatic breast cancer. Thus metastatic breast cancer joins a range of cancers in which this easily measurable value can be used for clinical prognostication. Further use as a predictive value for specific treatments has a rationale and deserves to be investigated.
机译：背景。血小板计数升高通常与恶性肿瘤有关，并且已被证实是包括早期乳腺癌在内的各种癌症的不良预后因素。我们试图确定血小板增多症是否也是转移性乳腺癌的预后因素。患者和方法。回顾了165例完全随访且具有血小板增多或血小板计数正常的转移性乳腺癌患者的记录。绘制了Kaplan-Meier曲线，并使用LogRank检验比较了两组的生存率。使用Cox回归分析来确定血小板增多是否是总体生存和无进展生存的独立因素。总体上和无进展生存期在统计学上有显着差异，偏向正常血小板组（LogRank testP = 0.038和0.008，分别）。在多变量分析中，血小板增多症仍是重要的不良预后因素。总体生存率的其他独立预后因素包括年龄，ER / PR状态和等级。血小板增多代表转移性乳腺癌患者的独立不良预后因素。因此，转移性乳腺癌加入了一系列癌症，在该癌症中，这种易于测量的价值可用于临床预后。进一步用作特定治疗的预测价值具有基本原理，值得研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号