Electrochemical Determination of Amsacrine at a ds-DNA Modified Graphene Carbon Paste Electrode and its Application as a Label-free Electrochemical Biosensor

Hadi Mahmoudi Moghaddam; Hadi Beitollahi; Gholamreza Dehghannoudeh; Hamid Forootanfar

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Electrochemical Determination of Amsacrine at a ds-DNA Modified Graphene Carbon Paste Electrode and its Application as a Label-free Electrochemical Biosensor

机译：ds-DNA修饰的石墨烯碳糊电极在电极上电化学测定Amsacrine及其在无标记电化学生物传感器中的应用

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The interaction between amsacrine and double stranded deoxyribonucleic acid (ds-DNA) was studied by a graphene paste electrode (GPE) and incubation solution using differential pulse voltammetry (DPV). A simple and sensitive biosensor was made using the mentioned interaction for determining amsacrine. DPV shows a linear dynamic range from 7.0 × 10?7 to1.0 × 10?4 M for amsacrine. The use of this screening method for analyzing real sample was studied with applying the proposed method to determine amsacrine in urine and blood serum. Generally, the findings indicated a DNA sensor with the ability to analyze the amsacrine in real samples effectively.

机译：通过石墨烯糊电极（GPE）和使用差分脉冲伏安法（DPV）的孵育溶液，研究了氨ac碱与双链脱氧核糖核酸（ds-DNA）之间的相互作用。使用所提及的相互作用来测定氨酚碱制成了一种简单而灵敏的生物传感器。 DPV显示出氨苯胺的线性动态范围从7.0×10？7到1.0×10？4M。研究了该筛选方法在分析真实样品中的应用，并结合所提出的方法测定尿液和血清中的氨苄西林。通常，研究结果表明，DNA传感器具有有效分析实际样品中氨水碱的能力。

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《International Journal of Electrochemical Science》 |2017年第11期|共14页
作者
Hadi Mahmoudi Moghaddam; Hadi Beitollahi; Gholamreza Dehghannoudeh; Hamid Forootanfar;
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7. Electrochemical Determination of Amsacrine at a ds-DNA Modified Graphene Carbon Paste Electrode and its Application as a Label-free Electrochemical Biosensor [O] . Hadi Mahmoudi Moghaddam 2017

机译：DS-DNA改性石墨烯碳浆电极在无氨基碱的电化学测定及其作为无标记电化学生物传感器的应用

Electrochemical Determination of Amsacrine at a ds-DNA Modified Graphene Carbon Paste Electrode and its Application as a Label-free Electrochemical Biosensor

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