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首页> 外文期刊>International Journal of Electrochemical Science >Fabrication of Electrochemical Immunosensor for Interferon-γ Determination and Its Application of Tuberculosis Diagnosis
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Fabrication of Electrochemical Immunosensor for Interferon-γ Determination and Its Application of Tuberculosis Diagnosis

机译：用于γ-干扰素测定的电化学免疫传感器的制备及其在结核病诊断中的应用

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Tuberculosis (TB), as one kind of infectious diseases caused by Mycobacterium tuberculosis, has killed countless numbers of people especially in underdeveloped countries. In our study, a label-free electrochemical immunosensor for the detection of interferon gamma (IFN-γ) was prepared for the first time. ZnO NPs prepared by hydrothermal method were used for the immobilization of IFN-γ monoclonal antibody. The increased impedance values displayed linear relationship with the logarithmic value of IFN-γ concentrations within the range of 0.0001 to 0.1 ng/mL. In addition, the detection limit was 0.12 pg/mL (S/N=3). The as-proposed immunosensor demonstrated promising potential usage in the diagnosis of tuberculosis in time owing to its simple operation, excellent sensitivity and stability.
机译：结核病是由结核分枝杆菌引起的一种传染病，已经杀死了无数人，特别是在不发达国家。在我们的研究中，首次制备了用于检测干扰素γ（IFN-γ）的无标记电化学免疫传感器。采用水热法制备的ZnO纳米粒被用于固定IFN-γ单克隆抗体。增加的阻抗值与0.000-0.1 ng / mL范围内的IFN-γ浓度的对数值呈线性关系。另外，检出限为0.12pg / mL（S / N ＝ 3）。提议的免疫传感器由于其简单的操作，出色的灵敏度和稳定性，在及时诊断结核病方面显示出有希望的潜在用途。

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