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首页> 外文期刊>International Journal of Electrochemical Science >Improved Determination of Mebeverine Hydrochloride in Urine, Serum and Pharmaceutical Preparations Utilizing a Modified Carbon Paste Electrode
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Improved Determination of Mebeverine Hydrochloride in Urine, Serum and Pharmaceutical Preparations Utilizing a Modified Carbon Paste Electrode

机译：修饰碳糊电极改进测定尿液，血清和药物制剂中盐酸美贝维林的方法

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摘要

A simple, rapid and sensitive method for the determination of mebeverine hydrochloride (MBHCl) inurine, serum and pharmaceutical preparations using modified carbon paste electrodes was developed.-7 -2 -7 The electrochemical sensors showed a linear dynamic range of 3.0 10 1.0 10 and 1.0 10 -2 -1 -7 -7 -1 1.0 10 mol L with detection limit of 3.010 and 110 mol L for modified carbon paste(MCPEs; sensors I and II), respectively. The slopes of the calibration graphs are 56.780.85 and-1 58.800.46 mV decade for MCPEs with tricresylphosphate (TCP) (sensor I) and o- nitrophenyloctylether (o-NPOE) (sensor II) as plasticizers, respectively. The response time wasrelatively quick in the whole concentration range (8 and 7 s), respectively. The electrodes can be usedat least 65 and 73 days without observing any deviations in a pH range of 2.0.0 and 1.5.0 forelectrodes I and II, respectively. The fabricated electrodes displayed good selectivity for MBHCl withrespect to number of common foreign inorganic cations, sugar species, and glycine as the fillers thatmay be added to the pharmaceutical preparation. Fortunately, such materials mostly do not interfere.The sensors were successfully applied for the determination of MBHCl in its tablets, urine and serum.The results obtained using these potentiometric electrodes were comparable with those obtained usingofficial method.
机译：建立了一种简单，快速，灵敏的方法，即使用修饰的碳糊电极测定盐酸美贝维林（MBHCl）中的尿样，血清和药物制剂。-7-2 -7电化学传感器的线性动态范围为3.0 10 1.0 10和1.0 10 -2 -1 -7 -7 -1 1.0 10 mol L，改性碳糊（MCPE;传感器I和II）的检出限分别为3.010和110 molL。对于带有三甲苯基磷酸酯（TCP）（传感器I）和邻硝基苯基辛基醚（o-NPOE）（传感器II）作为增塑剂的MCPE，校准曲线的斜率分别为56.780.85和-1 58.800.46 mV。在整个浓度范围内（8和7 s），响应时间相对较快。电极可以使用至少65天和73天，而在电极I和II的pH范围分别为2.0.0和1.5.0时不会出现任何偏差。相对于可以添加到药物制剂中的常见外来无机阳离子，糖类和甘氨酸等填充物，制备的电极对MBHCl具有良好的选择性。幸运的是，这些材料几乎不会干扰。传感器成功用于片剂，尿液和血清中MBHCl的测定。使用这些电位电极获得的结果与使用官方方法获得的结果相当。

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