Voltammetric Determination of the Cough Suppressant Drug Dropropizine in its Pharmaceutical Formulations and Human Urine

Sayed. I. M. Zayed; Hassan. A. M. Arida

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Voltammetric Determination of the Cough Suppressant Drug Dropropizine in its Pharmaceutical Formulations and Human Urine

机译：伏安法测定止咳药dropropizine的药物配方和人尿液

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The electrochemical behavior of dropropizine at carbon paste electrodes was investigated in 0.04 MBritton-Robinson buffer pH 6.25 using cyclic and differential pulse voltammetric methods. Cyclicvoltammetric studies indicated that the oxidation of dropropizine at the electrode surface wasirreversible, and mainly controlled by diffusion. Based on this a sensitive and simple differential pulsevoltammetric procedure has been developed for determination of the drug over the concentration range0.24 -2.36 g/ml, with detection and quantification limits of 0.046 and 0.152 g/ml, respectively. Thedeveloped method was successfully applied to the determination of dropropizine in lozenges tablets,and spiked human urine.

机译：使用循环和差分脉冲伏安法在0.04 MBritton-Robinson缓冲液pH 6.25中研究了ropropizine在碳糊电极上的电化学行为。循环伏安研究表明，dropropizine在电极表面的氧化是不可逆的，并且主要受扩散控制。基于此，开发了一种灵敏且简单的差分脉冲伏安法测定浓度范围为0.24 -2.36 g / ml的药物，检测和定量限分别为0.046和0.152 g / ml。所开发的方法已成功地用于锭剂片剂和人尿中加标的滴西哌嗪的测定。

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《International Journal of Electrochemical Science》 |2015年第4期|共10页
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Sayed. I. M. Zayed; Hassan. A. M. Arida;
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1. Studies on the Human Metabolism and the Toxicologic Detection of the Cough Suppressant Dropropizine in Urine Using Gas Chromatography-Mass Spectrometry. [J] . Staack RF, Maurer HH Therapeutic Drug Monitoring . 2004,第4期

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Voltammetric Determination of the Cough Suppressant Drug Dropropizine in its Pharmaceutical Formulations and Human Urine

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