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首页> 外文期刊>International Journal of Electrochemical Science >Electrochemical Methods for Detecting β-Amyloid Peptides and Monitoring Their Aggregation
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Electrochemical Methods for Detecting β-Amyloid Peptides and Monitoring Their Aggregation

机译：检测β-淀粉样肽并监测其聚集的电化学方法

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摘要

Amyloid- (A) peptides, the major constituent of the senile plaques in brain of Alzheimer disease(AD) patient, have been regarded as the reliable molecular biomarkers and therapeutic targets for thediagnosis and prognosis of AD. The aggregation of A is also believed to be a critical step in theaetiology of AD. Recently, electrochemical techniques have been successfully used to selectivelydetect kinds of A species and monitor the oligomerisation and assembly of A because of their highsensitivity, simplicity, rapid response, and compatibility with miniaturization. In this work, wesummarized the progress in the development of electrochemical methods for detecting A peptides andmonitoring their aggregation.
机译：淀粉样蛋白（A）肽是阿尔茨海默病（AD）患者脑部老年斑的主要成分，已被视为可靠的分子生物标志物和AD诊断和预后的治疗靶标。 A的聚集也被认为是AD神学的关键步骤。近来，由于电化学技术的高灵敏度，简单性，快速响应性以及与小型化的相容性，电化学技术已成功用于选择性地检测A类物质并监测A的低聚和组装。在这项工作中，我们总结了用于检测A肽和监测其聚集的电化学方法的进展。

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