PROTEIN TYROSINE PHOSPHATASE-LIKE PROTEIN IA2 ANTIBODIES AND GLUTAMIC ACID DECARBOXYLASE 65 ANTIBODIES (GADA) ARE NOT ASSOCIATED WITH SARCOIDOSIS

PAPADOPOULOS K.I.; GORAN S.; HENRIK B.; BENGT H.

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PROTEIN TYROSINE PHOSPHATASE-LIKE PROTEIN IA2 ANTIBODIES AND GLUTAMIC ACID DECARBOXYLASE 65 ANTIBODIES (GADA) ARE NOT ASSOCIATED WITH SARCOIDOSIS

机译：蛋白质酪氨酸磷酸酶样蛋白质IA2抗体和谷氨酸脱羧酶65抗体（GADA）与SARCOIDOSSIS无关

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The existence of an association between glutamic acid decarboxylase 65 antibodies (GADA) and/or IA2 antibodies and sarcoidosis was evaluated.Materials and Methods: 78 patients with documented sarcoidosis, divided according to the presence (N=37) or absence (N=41) of autoimmune manifestations were evaluated for GADA and IA2 antibodies using, a radioligand assay with human recombinant 35S-labeled GAD65 and IA2 respectively.Results: Two patients with GADA (2.6%) and one (1.3%) with IA2ab, both in the group of patients with autoimmunity associated sarcoidosis were found. The GADA positive patient had manifest Type 1 diabetes that succeeded sarcoidosis.IA2 ab-positivity was seen among patients with isolated sarcoidosis. GADA and IA2ab frequencies were not increased compared to reference subjects (2-3%).Conclusions: No clear association between sarcoidosis and GADA and/or IA2ab was found. In patients with sarcoidosis, GADA seem to be associated with type 1 diabetes or other autoimmune manifestations rather than with sarcoidosis per se.

机译：评估了谷氨酸脱羧酶65抗体（GADA）和/或IA2抗体与结节病之间的相关性。材料与方法：78例有结节病的患者，根据是否存在（N = 37）或不存在（N = 41）进行划分分别用人类重组35S标记的GAD65和IA2进行放射性配体测定，评估自身免疫性表现的GADA和IA2抗体。结果：该组中有2例GADA（2.6％）和1例（1.3％）IA2ab。发现有自身免疫性结节病的患者。 GADA阳性患者有结节病继发的明显1型糖尿病。在孤立结节病患者中观察到IA2阳性。与参考对象（2-3％）相比，GADA和IA2ab的频率没有增加。结论：结节病和GADA和/或IA2ab之间没有明确的关联。在结节病患者中，GADA似乎与1型糖尿病或其他自身免疫表现有关，而不是结节病本身。

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《International Journal of Endocrinology and Metabolism》 |2006年第3期|共4页
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PAPADOPOULOS K.I.; GORAN S.; HENRIK B.; BENGT H.;
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1. Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus [J] . G?ran Sundkvist, Henrik Borg, Per Fernlund Clinical Chemistry: Journal of the American Association for Clinical Chemists . 1997,第12期

机译：蛋白酪氨酸磷酸酶样蛋白IA2-抗体加谷氨酸脱羧酶65抗体（GADA）表明，对于最近诊断为糖尿病的儿童，自身免疫与胰岛细胞抗体检测一样频繁
2. Tyrosine phosphatase-like protein (IA-2) and glutamic acid decarboxylase (GAD65) autoantibodies: a study of Chinese patients with diabetes mellitus. [J] . Ng WY, Lee YS, Todd AL, Autoimmunity . 2002,第2期

机译：酪氨酸磷酸酶样蛋白（IA-2）和谷氨酸脱羧酶（GAD65）自身抗体：对中国糖尿病患者的一项研究。
3. Measurement of antibodies against glutamic acid decarboxylase 65 (GADA): two new 125I assays compared with [35S]GAD 65-ligand binding assay [J] . G?ran Sundkvist, Henrik Borg, Per Fernlund Clinical Chemistry: Journal of the American Association for Clinical Chemists . 1997,第5期

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4. Study on interaction between ampicillin antibody and detection interfering proteins by computer aided protein-protein docking for biosensor interesting [C] . Wang Minghua, Wang Jianping IEEE 5th International Bio-Inspired Computing: Theories and Applications . 2010

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7. Protein tyrosine phosphatase-like protein IA2-antibodies plus glutamic acid decarboxylase 65 antibodies (GADA) indicates autoimmunity as frequently as islet cell antibodies assay in children with recently diagnosed diabetes mellitus [O] . Henrik Borg, Per Fernlund, Göran Sundkvist 1997

机译：蛋白质酪氨酸磷酸酶样蛋白IA2-抗体加上谷氨酸脱羧酶65抗体（GADA）表明患有最近诊断糖尿病患儿的胰岛细胞抗体测定的自身免疫

PROTEIN TYROSINE PHOSPHATASE-LIKE PROTEIN IA2 ANTIBODIES AND GLUTAMIC ACID DECARBOXYLASE 65 ANTIBODIES (GADA) ARE NOT ASSOCIATED WITH SARCOIDOSIS

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