首页> 外文期刊>International Journal of Food Science and Biotechnology >Toxic Effects of Coralene Red XF and Remazol Red RR Textile Dyes on Liver and Kidney in Mice
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Toxic Effects of Coralene Red XF and Remazol Red RR Textile Dyes on Liver and Kidney in Mice

机译:珊瑚红XF和Remazol红RR纺织染料对小鼠肝脏和肾脏的毒性作用

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Adulterated food is a silent killer. Dishonest traders used textile dyes as adulterant in different foods as unethical practices. Moreover, textile industries also throw waste dye as effluent in ground water. In this study, we investigated the toxic effects of two textile dyes Coralene Red XF and Remazol Red RR by in vivo experiments in mice. Mice were administered Coralene Red XF and Remazol Red RR textile dyes at a single oral dose of 0.04g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SUR) and histopathology of liver and kidney. The levels of AST, ALT, STBI, SUR and SCR were found to be increased by both Coralene Red XF and Remazol Red RR. Histopathological examination of liver showed inflammatory atypia of hepatocytes and inflamation also observed in kidney.
机译:掺假食品是沉默的杀手。不诚实的商人使用纺织染料作为不道德行为在不同食品中掺假。此外,纺织工业还将废染料作为废水排放到地下水中。在这项研究中,我们通过小鼠体内实验研究了两种纺织染料Coralene Red XF和Remazol Red RR的毒性作用。每天以0.04g / kg的单次口服剂量向小鼠施用Coralene Red XF和Remazol Red RR纺织染料,持续21天,以观察这些染料对小鼠的任何毒性作用。通过测量血清天冬氨酸转氨酶(AST),谷氨酸丙酮酸转氨酶(ALT),血清总胆红素(STBI),血清肌酐(SCR),血清尿素(SUR)以及肝脏和肾脏的组织病理学来评估毒性作用。发现Coralene Red XF和Remazol Red RR均可提高AST,ALT,STBI,SUR和SCR的水平。肝脏的组织病理学检查显示,肝细胞具有炎症性异型性,肾脏也可见炎症。

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