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首页> 外文期刊>International Journal of Environmental Research and Public Health >Paternal Risk Factors for Oral Clefts in Northern Africans, Southeast Asians, and Central Americans
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Paternal Risk Factors for Oral Clefts in Northern Africans, Southeast Asians, and Central Americans

机译：北部非洲人，东南亚人和中美洲人口裂的父亲风险因素

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While several studies have investigated maternal exposures as risk factors for oral clefts, few have examined paternal factors. We conducted an international multi-centered case–control study to better understand paternal risk exposures for oral clefts (cases = 392 and controls = 234). Participants were recruited from local hospitals and oral cleft repair surgical missions in Vietnam, the Philippines, Honduras, and Morocco. Questionnaires were administered to fathers and mothers separately to elicit risk factor and family history data. Associations between paternal exposures and risk of clefts were assessed using logistic regression adjusting for potential confounders. A father’s personal/family history of clefts was associated with significantly increased risk (adjusted OR: 4.77; 95% CI: 2.41–9.45). No other significant associations were identified for other suspected risk factors, including education (none/primary school v. university adjusted OR: 1.29; 95% CI: 0.74–2.24), advanced paternal age (5-year adjusted OR: 0.98; 95% CI: 0.84–1.16), or pre-pregnancy tobacco use (adjusted OR: 0.96; 95% CI: 0.67–1.37). Although sample size was limited, significantly decreased risks were observed for fathers with selected occupations. Further research is needed to investigate paternal environmental exposures as cleft risk factors.
机译：尽管有几项研究调查了母亲暴露作为口腔裂口的危险因素，但很少有研究检查了父亲因素。我们进行了一项国际多中心病例对照研究，以更好地了解口裂的父亲风险暴露（病例= 392，对照= 234）。参与者是从当地医院招募的，并在越南，菲律宾，洪都拉斯和摩洛哥进行了唇裂修复手术。分别对父亲和母亲进行问卷调查，以得出危险因素和家族史数据。使用对潜在混杂因素进行逻辑回归调整，评估父亲暴露与c裂风险之间的关联。父亲的个人/家族裂痕病史与患病风险显着增加有关（校正后的OR：4.77; 95％CI：2.41-9.45）。没有发现其他可疑风险因素的其他显着关联，包括教育程度（无/小学诉大学调整后的OR：1.29; 95％CI：0.74-2.24），父系年龄较大（5年调整后的OR：0.98; 95％ CI：0.84-1.16）或孕前吸烟（调整后的OR：0.96; 95％CI：0.67-1.37）。尽管样本量有限，但发现从事某些职业的父亲的风险明显降低。需要进一步的研究来调查父亲的环境暴露作为唇裂的危险因素。

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