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首页> 外文期刊>International Journal of Environmental Research and Public Health >Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls
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Immunotoxicity Monitoring in a Population Exposed to Polychlorinated Biphenyls

机译：暴露于多氯联苯的人群中的免疫毒性监测

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The relationship between polychlorinated biphenyl (PCB) burden and several indicators of immune function was investigated as part of the HELPcB (Health Effects in High-Level Exposure to PCB) program, offering bio-monitoring to workers, relatives, and neighbors exposed to PCBs by a German transformers and capacitors recycling company. The present retrospective observational study evaluates the correlation of plasma levels of total PCBs, five indicator congeners (28, 101, 138, 153, 180), and seven dioxin-like congeners (105, 114, 118, 156, 157, 167, 189) with several parameters of immune function. The cross-sectional study was performed immediately after the end of exposure (258 subjects), and one (218 subjects), and two (177 subjects) years later. At the first time point, measurements showed significant positive correlation between congeners with low to medium chlorination and the relative proportion of CD19 positive B-cells among lymphocytes, as well as a negative correlation of PCB114 with serum IgM, and of PCB 28 with suppressor T-cell and NK-cell numbers. Congeners with a high degree of chlorination, in particular PCB157 and 189, were positively associated with expression of the activation marker CD25 on T-cells in the cohort of the second time point. No associations between PCB levels and IFN-y production by T-cells and killing by NK-cells were found. In conclusion, there were several effects on the cellular composition of adaptive immunity, affecting both T- and B-cells. However, the values were not generally outside the reference ranges for healthy adult individuals and did not indicate overt functional immunodeficiency, even in subjects with the uppermost PCB burden.
机译：作为HELPcB（高水平暴露于PCB的健康影响）计划的一部分，调查了多氯联苯（PCB）负担与若干免疫功能指标之间的关系，该方法对通过PCB暴露的工人，亲戚和邻居提供了生物监测。一家德国变压器和电容器回收公司。本回顾性观察研究评估了总PCB的血浆水平，五个指标同类物（28、101、138、153、180）和七个二恶英样同类物（105、114、118、156、157、167、189）的相关性）具有免疫功能的几个参数。横断面研究是在暴露结束后（258名受试者），一年（218名受试者）和两年（177名受试者）结束后立即进行的。在第一个时间点，测量结果显示低至中度氯化物的同类物与淋巴细胞中CD19阳性B细胞的相对比例之间显着正相关，PCB114与血清IgM呈负相关，PCB 28与抑制剂T呈负相关。 -cell和NK-cell编号。具有高氯化度的同类物，特别是PCB157和189，与第二时间点队列中T细胞上活化标记CD25的表达呈正相关。没有发现PCB水平与T细胞产生IFN-γ和NK细胞杀死细胞之间有关联。总之，对适应性免疫的细胞组成有多种影响，既影响T细胞又影响B细胞。但是，该值通常不会超出健康成年人的参考范围，并且即使在PCB负担最大的受试者中也不能显示明显的功能性免疫缺陷。

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