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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies
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The Effect of Vitamin A on Fracture Risk: A Meta-Analysis of Cohort Studies

机译：维生素A对骨折风险的影响：一项队列研究的荟萃分析

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This meta-analysis evaluated the influence of dietary intake and blood level of vitamin A (total vitamin A, retinol or β-carotene) on total and hip fracture risk. Cohort studies published before July 2017 were selected through English-language literature searches in several databases. Relative risk (RR) with corresponding 95% confidence interval (CI) was used to evaluate the risk. Heterogeneity was checked by Chi-square and I 2 test. Sensitivity analysis and publication bias were also performed. For the association between retinol intake and total fracture risk, we performed subgroup analysis by sex, region, case ascertainment, education level, age at menopause and vitamin D intake. R software was used to complete all statistical analyses. A total of 319,077 participants over the age of 20 years were included. Higher dietary intake of retinol and total vitamin A may slightly decrease total fracture risk (RR with 95% CI: 0.95 (0.91, 1.00) and 0.94 (0.88, 0.99), respectively), and increase hip fracture risk (RR with 95% CI: 1.40 (1.02, 1.91) and 1.29 (1.06, 1.57), respectively). Lower blood level of retinol may slightly increase total fracture risk (RR with 95% CI: 1.11 (0.94, 1.30)) and hip fracture risk (RR with 95% CI: 1.27 (1.05, 1.53)). In addition, higher β-carotene intake was weakly associated with the increased risk of total fracture (RR with 95% CI: 1.07 (0.97, 1.17)). Our data suggest that vitamin A intake and level may differentially influence the risks of total and hip fractures. Clinical trials are warranted to confirm these results and assess the clinical applicability.
机译：这项荟萃分析评估了饮食摄入和血液中维生素A（总维生素A，视黄醇或β-胡萝卜素）的水平对总骨折风险和髋部骨折风险的影响。通过英语文献检索在多个数据库中选择了2017年7月之前发表的队列研究。使用具有相对应的95％置信区间（CI）的相对风险（RR）来评估风险。通过卡方检验和I 2检验检查异质性。还进行了敏感性分析和出版物偏倚。对于视黄醇摄入与总骨折风险之间的关系，我们按性别，地区，病例确定，教育程度，绝经年龄和维生素D摄入量进行了亚组分析。使用R软件来完成所有统计分析。总共包括319,077名20岁以上的参与者。较高的饮食摄入视黄醇和总维生素A可能会稍微降低总的骨折风险（RR的95％CI：0.95（0.91，1.00）和0.94（0.88，0.99），分别），并增加髋部骨折的风险（RR 95％CI的RR） ：1.40（1.02，1.91）和1.29（1.06，1.57）。降低视黄醇的血液水平可能会稍微增加总的骨折风险（RR占95％CI：1.11（0.94，1.30））和髋部骨折的风险（RR占95％CI：1.27（1.05，1.53））。此外，较高的β-胡萝卜素摄入与总骨折风险增加之间存在弱关联（RR 95％CI：1.07（0.97，1.17））。我们的数据表明，维生素A的摄入量和水平可能会不同地影响全髋骨折的风险。必须进行临床试验以确认这些结果并评估临床适用性。

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