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首页> 外文期刊>International Journal of Environmental Research and Public Health >Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors
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Biomarker Genes for Detecting Estrogenic Activity of Endocrine Disruptors via Estrogen Receptors

机译：生物标志物基因通过雌激素受体检测内分泌干扰物的雌激素活性

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摘要

Endocrine disruptors (EDs) are compounds used in various industrial products, drugs, and cosmetics. They can be found in the environment and disturb the endocrine and reproductive systems, resulting in adverse effects to humans and wildlife such as birth defects and developmental disorders. Since several EDs have a structure similar to that of endogenous steroid hormones such as estrogens, they intend to have an affinity for steroid hormone receptors and alter hormone-mediated metabolism by binding to these receptors. EDs are therefore a global concern and assays should be developed to efficiently determine whether these compounds are detrimental to biological systems. Diverse experimental methods may help determine the endocrine disrupting potential of EDs and evaluate the adverse effects of a single and/or combination of these reagents. Currently, biomarkers have been employed to objectively measure EDs potency and understand the underlying mechanisms. Further studies are required to develop ideal screening methods and biomarkers to determine EDs potency at environmentally relevant concentrations. In this review, we describe the biomarkers for estrogenicity of EDs identified both in vitro and in vivo, and introduce a biomarker, cabindin-D9k (CaBP-9k), that may be used to assess estrogenic activity of EDs.
机译：内分泌干​​扰物（ED）是用于各种工业产品，药品和化妆品中的化合物。它们可以在环境中发现并扰乱内分泌和生殖系统，从而对人类和野生生物产生不良影响，例如先天缺陷和发育障碍。由于几种ED具有类似于内源性类固醇激素（例如雌激素）的结构，因此它们打算对类固醇激素受体具有亲和力，并通过与这些受体结合而改变激素介导的代谢。因此，EDs是全球关注的问题，应开发测定方法以有效确定这些化合物是否对生物系统有害。多样的实验方法可能有助于确定ED的内分泌破坏潜能，并评估这些试剂的单一和/或组合的不良作用。目前，已经使用生物标记物客观地测量ED的效力并了解其潜在机制。需要开展进一步的研究来开发理想的筛选方法和生物标记物，以测定环境相关浓度下的EDs效能。在这篇综述中，我们描述了在体外和体内鉴定的EDs的雌激素生物标志物，并介绍了一种生物标志物cabindin-D9k（CaBP-9k），可用于评估EDs的雌激素活性。

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