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Incidence Density and Risk Factors of Diabetic Retinopathy Within Type 2 Diabetes: A Five-Year Cohort Study in China (Report 1)

机译:2型糖尿病患者糖尿病性视网膜病变的发病率密度和危险因素:中国一项为期五年的队列研究(报告1)

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A prospective study was carried out from August 2010 to August 2014 in the community of Fengyutan (China). Six hundred and twenty two T2D subjects were collected. The incidence density of diabetic retinopathy (DR) was 1.81% person-year (95% confidence interval, CI: 1.21–2.43% person-year). After a Cox regression model analysis and adjusted confounding factors, independent predictors related to the incidence of DR including male gender (adjusted hazard ratios, aHR: 1.47, 95% CI: 1.21–1.62), with hypertension (aHR: 1.49, 95%: 1.12–1.73), duration of diabetes > 10 years (aHR: 2.28, 95%: 2.05–2.42), uncontrolled diabetes (aHR: 1.76, 95%: 1.41–2.01), total cholesterol ≥ 200 mg/dL (aHR: 1.54, 95%: 1.34–1.72) and HbA1c ≥ 7% (mmol/mol) (aHR: 2.12, 95%: 1.87–2.32). Duration of T2D revealed the significantly dose-response relationship to the onset of DR. The incidence density of DR in the Chinese community was relatively low in comparison with other studies. More attention should be paid to the T2D patients, especially of male gender, with hypertension, longer duration of diabetes, uncontrolled diabetes, total cholesterol ≥ 200mg/dL and HbA1c ≥ 7% (mmol/mol).
机译:从2010年8月至2014年8月,在中国风玉潭社区进行了一项前瞻性研究。收集了622个T2D主题。糖尿病性视网膜病(DR)的发生密度为1.81%人年(95%置信区间,CI:1.21–2.43%人年)。经过Cox回归模型分析并调整了混杂因素后,与DR发生率相关的独立预测因子包括男性(调整后的危险比,aHR:1.47,95%CI:1.21-1.62),高血压(aHR:1.49,95%: 1.12–1.73),糖尿病持续时间大于10年(aHR:2.28、95%:2.05–2.42),非对照糖尿病(aHR:1.76、95%:1.41-2.01),总胆固醇≥200 mg / dL(aHR:1.54) ,95%:1.34–1.72)和HbA1c≥7%(mmol / mol)(aHR:2.12,95%:1.87–2.32)。 T2D的持续时间显示出与DR发作显着的剂量反应关系。与其他研究相比,华人社区中DR的发生密度相对较低。患有高血压,糖尿病病程较长,糖尿病未控制,总胆固醇≥200mg / dL和HbA1c≥7%(mmol / mol)的T2D患者,尤其是男性,应引起更多重视。

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