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首页> 外文期刊>International Journal of Environmental Research and Public Health >Molecular Aspects of Dopaminergic Neurodegeneration: Gene-Environment Interaction in Parkin Dysfunction
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Molecular Aspects of Dopaminergic Neurodegeneration: Gene-Environment Interaction in Parkin Dysfunction

机译：多巴胺能神经变性的分子方面：帕金功能障碍的基因-环境相互作用。

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摘要

Parkinson’s disease (PD) is a common neurodegenerative movement disorder that is characterized pathologically by a progressive loss of midbrain dopaminergic neurons and by protein inclusions, designated Lewy bodies and Lewy neurites. PD is one of the most common neurodegenerative diseases, affecting almost 1% of the population over 60 years old. Although the symptoms and neuropathology of PD have been well characterized, the underlying mechanisms and causes of the disease are still not clear. Genetic mutations can provide important clues to disease mechanism, but most PD cases are sporadic rather than familial; environmental factors have long been suspected to contribute to the disease. Although more than 90% of PD cases occur sporadically and are thought to be due, in part, to oxidative stress and mitochondrial dysfunction, the study of genetic mutations has provided great insight into the molecular mechanisms of PD. Furthermore, rotenone, a widely used pesticide, and paraquat and maneb cause a syndrome in rats and mice that mimics, both behaviorally and neurologically, the symptoms of PD. In the current review, we will discuss various aspects of gene-environment interaction that lead to progressive dopaminergic neurodegenration, mainly focusing on our current finding based on stress-mediated parkin dysfunction.
机译：帕金森氏病（PD）是一种常见的神经退行性运动障碍，其病理特征是中脑多巴胺能神经元的进行性丧失和蛋白质包裹体，称为路易体和路易神经突。 PD是最常见的神经退行性疾病之一，影响60岁以上人口的近1％。尽管已经很好地表征了PD的症状和神经病理学，但尚不清楚该疾病的潜在机制和病因。基因突变可以为疾病机理提供重要线索，但是大多数PD病例是散发性而非家族性的。长期以来，人们一直怀疑环境因素会导致这种疾病。尽管超过90％的PD病例是偶发性的，并且部分原因是由于氧化应激和线粒体功能障碍，但是基因突变的研究为PD的分子机制提供了深刻的见识。此外，鱼藤酮（一种广泛使用的杀虫剂）以及百草枯和马尼布会在大鼠和小鼠中引起一种在行为和神经学上都模仿PD症状的综合征。在当前的审查中，我们将讨论导致进行性多巴胺能神经退行性变的基因-环境相互作用的各个方面，主要集中在我们当前基于应激介导的帕金功能障碍的研究中。

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