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首页> 外文期刊>International Journal of Environmental Research and Public Health >A Methodological Approach to Assessing the Health Impact of Environmental Chemical Mixtures: PCBs and Hypertension in the National Health and Nutrition Examination Survey
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A Methodological Approach to Assessing the Health Impact of Environmental Chemical Mixtures: PCBs and Hypertension in the National Health and Nutrition Examination Survey

机译：评估环境化学混合物对健康的影响的方法论方法：国家健康与营养检查中的多氯联苯和高血压

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摘要

We describe an approach to examine the association between exposure to chemical mixtures and a health outcome, using as our case study polychlorinated biphenyls (PCBs) and hypertension. The association between serum PCB and hypertension among participants in the 1999–2004 National Health and Nutrition Examination Survey was examined. First, unconditional multivariate logistic regression was used to estimate odds ratios and associated 95% confidence intervals. Next, correlation and multicollinearity among PCB congeners was evaluated, and clustering analyses performed to determine groups of related congeners. Finally, a weighted sum was constructed to represent the relative importance of each congener in relation to hypertension risk. PCB serum concentrations varied by demographic characteristics, and were on average higher among those with hypertension. Logistic regression results showed mixed findings by congener and class. Further analyses identified groupings of correlated PCBs. Using a weighted sum approach to equalize different ranges and potencies, PCBs 66, 101, 118, 128 and 187 were significantly associated with increased risk of hypertension. Epidemiologic data were used to demonstrate an approach to evaluating the association between a complex environmental exposure and health outcome. The complexity of analyzing a large number of related exposures, where each may have different potency and range, are addressed in the context of the association between hypertension risk and exposure to PCBs.
机译：我们以多氯联苯（PCB）和高血压为例，描述了一种方法来检查化学混合物暴露与健康结果之间的关联。在1999–2004年美国国家健康和营养检查调查中，检查了参与者血清PCB与高血压之间的关联。首先，使用无条件多元logistic回归来估计比值比和相关的95％置信区间。接下来，评估PCB同类物之间的相关性和多重共线性，并进行聚类分析以确定相关同类物的组。最后，构建一个加权总和，以表示每个同类因素与高血压风险的相对重要性。 PCB血清浓度随人口统计学特征而变化，并且在高血压患者中平均较高。 Logistic回归结果表明，同类和分类的研究结果参差不齐。进一步的分析确定了相关PCB的分组。使用加权总和方法均衡不同的范围和效力，PCBs 66、101、118、128和187与高血压风险显着相关。流行病学数据用于证明评估复杂环境暴露与健康结果之间关联的方法。在高血压风险与多氯联苯暴露之间的关联的背景下，解决了分析大量相关暴露的复杂性，其中每种暴露可能具有不同的效力和范围。

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