Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their socio-demographic, immunological and clinical characteristics. A total of 1202 patients enrolled between 2000 and 2010 were included. They were grouped according to pancytopenia status, defined by having: platelets <150,000 μL, white cell count <4000 μL, and hemoglobin <12 g/dL (women) or <13 g/dL (men). Differences were evaluated using Student’s t-test, Chi-square test and Kaplan-Meier method. The prevalence of pancytopenia was 8.7%. Patients with pancytopenia had lower BMI and lower CD4 count, as well as higher HIV viral load and higher proportions of unemployment, clinical AIDS and antiretroviral treatment (ART) use (p < 0.05). One-year mortality rate was significantly higher in patients with pancytopenia (18.1% vs. 5.1%, p < 0.001). When stratifying for ART this association persisted for patients who did not receive ART (41.4% vs. 5.2%, p < 0.001), but it was not seen in patients who received treatment (9.2% vs. 5.6%, p = 0.196). Pancytopenia was associated with elements of advanced stages of HIV. ART could reduce the mortality of HIV-patients with pancytopenia to levels comparable to patients without the disorders.
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机译：晚期艾滋病毒感染中可见全血细胞减少症。它与医学并发症和存活率降低有关。我们确定了居住在波多黎各的一群HIV阳性西班牙裔人群中基线时全血细胞减少症的患病率，并比较了他们的社会人口统计学，免疫学和临床特征。纳入2000年至2010年期间的1202名患者。根据全血细胞减少症的状态将它们分组，定义为：血小板<150,000μL，白细胞计数<4000μL，血红蛋白<12 g / dL（女性）或<13 g / dL（男性）。差异采用Student's t检验，卡方检验和Kaplan-Meier方法进行评估。全血细胞减少症的患病率为8.7％。全血细胞减少症患者的BMI较低，CD4计数较低，HIV病毒载量较高，失业，临床艾滋病和抗逆转录病毒治疗（ART）的比例较高（p <0.05）。全血细胞减少症患者的一年死亡率显着较高（18.1％，vs.5.1％，p <0.001）。在对ART进行分层时，对于未接受ART的患者这种关联仍然存在（41.4％，对5.2％，p <0.001），但在接受治疗的患者中未见关联（9.2％，对5.6％）。 ％，p = 0.196）。全血细胞减少症与艾滋病晚期有关。 ART可以将患有全血细胞减少症的HIV患者的死亡率降低到与没有该疾病的患者相当的水平。
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