Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their socio-demographic, immunological and clinical characteristics. A total of 1202 patients enrolled between 2000 and 2010 were included. They were grouped according to pancytopenia status, defined by having: platelets 150,000 μL, white cell count 4000 μL, and hemoglobin 12 g/dL (women) or 13 g/dL (men). Differences were evaluated using Student’s t-test, Chi-square test and Kaplan-Meier method. The prevalence of pancytopenia was 8.7%. Patients with pancytopenia had lower BMI and lower CD4 count, as well as higher HIV viral load and higher proportions of unemployment, clinical AIDS and antiretroviral treatment (ART) use (p 0.05). One-year mortality rate was significantly higher in patients with pancytopenia (18.1% vs. 5.1%, p 0.001). When stratifying for ART this association persisted for patients who did not receive ART (41.4% vs. 5.2%, p 0.001), but it was not seen in patients who received treatment (9.2% vs. 5.6%, p = 0.196). Pancytopenia was associated with elements of advanced stages of HIV. ART could reduce the mortality of HIV-patients with pancytopenia to levels comparable to patients without the disorders.
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机译：晚期艾滋病毒感染中可见全血细胞减少症。它与医学并发症和存活率降低有关。我们确定了居住在波多黎各的一群HIV阳性西班牙裔人群中基线时全血细胞减少症的患病率，并比较了他们的社会人口统计学，免疫学和临床特征。纳入2000年至2010年期间的1202名患者。根据全血细胞减少症的状态将它们分组，定义为：血小板<150,000μL，白细胞计数<4000μL，血红蛋白<12 g / dL（女性）或<13 g / dL（男性）。差异采用Student's t检验，卡方检验和Kaplan-Meier方法进行评估。全血细胞减少症的患病率为8.7％。全血细胞减少症患者的BMI较低，CD4计数较低，HIV病毒载量较高，失业，临床艾滋病和抗逆转录病毒治疗（ART）的比例较高（p <0.05）。全血细胞减少症患者的一年死亡率显着更高（18.1％vs. 5.1％，p <0.001）。在对ART进行分层时，对于未接受ART的患者这一关联仍然存在（41.4％vs. 5.2％，p <0.001），但是在接受治疗的患者中未发现这一关联（9.2％vs. 5.6％，p = 0.196）。全血细胞减少症与艾滋病晚期有关。 ART可以将患有全血细胞减少症的HIV患者的死亡率降低到与没有该疾病的患者相当的水平。
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