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首页> 外文期刊>International Journal of Environmental Research and Public Health >The Geographic Distribution of Liver Cancer in Canada Does Not Associate with Cyanobacterial Toxin Exposure
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The Geographic Distribution of Liver Cancer in Canada Does Not Associate with Cyanobacterial Toxin Exposure

机译：加拿大肝癌的地理分布与蓝藻毒素暴露无关

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摘要

The incidence of liver cancer has been increasing in Canada over the past decade, as has cyanobacterial contamination of Canadian freshwater lakes and drinking water sources. Cyanotoxins released by cyanobacteria have been implicated in the pathogenesis of liver cancer. Objective: To determine whether a geographic association exists between liver cancer and surrogate markers of cyanobacterial contamination of freshwater lakes in Canada. Methods: A negative binomial regression model was employed based on previously identified risk factors for liver cancer. Results: No association existed between the geographic distribution of liver cancer and surrogate markers of cyanobacterial contamination. As predicted, significant associations existed in areas with a high prevalence of hepatitis B virus infection, large immigrant populations and urban residences. Discussion and Conclusions: The results of this study suggest that cyanobacterial contamination of freshwater lakes does not play an important role in the increasing incidence of liver cancer in Canada.
机译：在过去十年中，加拿大的肝癌发病率一直在增加，加拿大淡水湖泊和饮用水源的蓝细菌污染也在不断增加。蓝细菌释放的氰毒素与肝癌的发病机制有关。目的：确定肝癌与加拿大淡水湖泊中蓝细菌污染的替代标志物之间是否存在地理联系。方法：基于先前确定的肝癌危险因素，采用负二项式回归模型。结果：肝癌的地理分布与蓝细菌污染的替代标志物之间没有关联。如预测的那样，在乙型肝炎病毒感染率高，移民人口众多和城市居住的地区存在着显着的联系。讨论与结论：这项研究的结果表明，淡水湖泊中的蓝细菌污染在加拿大肝癌发病率增加中没有发挥重要作用。

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