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首页> 外文期刊>International Journal of Hepatology >Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?
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Serum Adiponectin, Vitamin D, and Alpha-Fetoprotein in Children with Chronic Hepatitis C: Can They Predict Treatment Response?

机译：慢性丙型肝炎患儿的血清脂联素，维生素D和甲胎蛋白可以预测治疗反应吗？

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Background & Aims. The currently available treatment for chronic hepatitis C (CHC) in children is costly and with much toxicity. So, predicting the likelihood of response before starting therapy is important.Methods. Serum adiponectin, vitamin D, and alpha-fetoprotein (AFP) were measured before starting pegylated-interferon/ribavirin therapy for 50 children with CHC. Another 21 healthy children were recruited as controls.Results. Serum adiponectin, vitamin D, and AFP were higher in the CHC group than healthy controls (p<0.0001,p=0.071, andp=0.87, resp.). In univariate analysis, serum adiponectin was significantly higher in responders than nonresponders (p<0.0001) and at a cutoff value ≥8.04 ng/mL it can predict treatment response by 77.8% sensitivity and 92.9% specificity, while both AFP and viremia were significantly lower in responders than nonresponders,p<0.0001andp=0.0003, respectively, and at cutoff values ≤3.265 ng/mL and ≤235,384 IU/mL, respectively, they can predict treatment response with a sensitivity of 83.3% for both and specificity of 85.7% and 78.6%, respectively. In multivariate analysis, adiponectin was found to be the only independent predictor of treatment response (p=0.044).Conclusions. The pretreatment serum level of adiponectin can predict the likelihood of treatment response, thus avoiding toxicities for those unlikely to respond to therapy.
机译：背景和目标。目前用于儿童慢性丙型肝炎（CHC）的治疗费用昂贵且毒性很大。因此，在开始治疗之前预测反应的可能性很重要。在开始使用聚乙二醇干扰素/利巴韦林治疗50例CHC患儿之前，先测定血清脂联素，维生素D和甲胎蛋白（AFP）。招募了另外21名健康儿童作为对照。 CHC组的血清脂联素，维生素D和AFP高于健康对照组（分别为p <0.0001，p = 0.071和p = 0.87）。在单变量分析中，应答者的血清脂联素显着高于无应答者（p <0.0001），并且在临界值≥8.04ng / mL时，可以通过77.8％的敏感性和92.9％的特异性预测治疗应答，而AFP和病毒血症均显着降低应答者比无应答者分别p <0.0001和p = 0.0003，并且在临界值分别≤3.2653.2ng/ mL和≤235,384IU / mL时，他们可以预测治疗应答，两者的敏感性均为83.3％，特异性为85.7％和78.6％。在多变量分析中，脂联素被发现是治疗反应的唯一独立预测因子（p = 0.044）。脂联素的预处理血清水平可以预测治疗反应的可能性，从而避免对那些不太可能对治疗产生反应的人产生毒性。

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