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首页> 外文期刊>International Journal of Molecular Epidemiology and Genetics >Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men
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Genetic screening for AZF Y chromosome microdeletions in Jordanian azoospermic infertile men

机译：约旦无精子症不育男性AZF Y染色体微缺失的遗传筛选

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摘要

The azoospermia factor (AZF) region of the human Y chromosome contains essential genes for spermatogenesis. Microdeletions in AZF region has been shown to cause male infertility. The aim of this investigation was to determine the frequency of AZF microdeletions in Jordanian infertile males. A sample of 100 infertile males (36 with azoospermia and 64 with oligozoospermia) was screened for microdeletions using 16 AZF markers and polymerase chain reaction (PCR) technique. Two subjects were found to have microdeletions in AZFc region and one subject has microdeletion that includes AZFb and part of AZFc and AZFa. The three deletions were found in azoospermic subjects (8.3%). No microdeletions were found in oligozoospermic group. The frequency of AZF microdeletions in Jordanian azoospermic infertile males is comparable to that observed in other populations (1%-15%). The results suggest the importance of AZF microdeletion analysis for genetic counseling prior to providing assisted reproduction technique.
机译：人Y染色体的无精症因子（AZF）区包含精子发生的必需基因。 AZF区的微缺失已显示可引起男性不育。这项研究的目的是确定约旦不育男性中AZF微缺失的频率。使用16个AZF标记和聚合酶链反应（PCR）技术，对100名不育男性（无精子症36名，少精子症64名）的样本进行了微缺失筛选。发现两名受试者在AZFc区有微缺失，一名受试者的微缺失包括AZFb和部分AZFc和AZFa。在无精子症患者中发现了三个缺失（8.3％）。少精子症组未发现微量缺失。约旦无精子症不育男性中AZF微缺失的频率与其他人群中观察到的频率相当（1％-15％）。结果表明，在提供辅助生殖技术之前，AZF微缺失分析对于遗传咨询非常重要。

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