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首页> 外文期刊>International journal of molecular imaging >Comparison of Cannabinoid CB1Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470
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Comparison of Cannabinoid CB1Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [18F]MK-9470

机译：青少年和成年大鼠中大麻素CB1受体结合的比较：正电子发射断层扫描研究，使用[18F] MK-9470

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Despite the important role of cannabinoid CB1receptors (CB1R) in brain development, little is known about their status during adolescence, a critical period for both the development of psychosis and for initiation to substance abuse. In the present study, we assessed the ontogeny of CB1R in adolescent and adult ratsin vivousing positron emission tomography with [18F]MK-9470. Analysis of covariance (ANCOVA) to control for body weight that would potentially influence [18F]MK-9470 values between the two groups revealed a main effect of age (F(1,109)=5.0,P=0.02) on [18F]MK-9470 absolute binding (calculated as percentage of injected dose) with adult estimated marginal means being higher compared to adolescents amongst 11 brain regions. This finding was confirmed usingin vitroautoradiography with [3H]CP55,940 (F(10,99)=140.1,P<0.0001). This ontogenetic pattern, suggesting increase of CB1R during the transition from adolescence to adulthood, is the opposite of most other neuroreceptor systems undergoing pruning during this period.
机译：尽管大麻素CB1受体（CB1R）在大脑发育中起着重要作用，但人们对其青春期的状态知之甚少，青春期是精神病发展和药物滥用引发的关键时期。在本研究中，我们使用[18F] MK-9470进行正电子发射断层扫描，评估了CB1R在青春期和成年大鼠体内的个体发育。分析协方差（ANCOVA）以控制可能会影响两组之间[18F] MK-9470值的体重，发现年龄对[18F] MK-具有主要影响（F（1,109）= 5.0，P = 0.02）在11个大脑区域中，成年人的边缘结合平均值为9470，绝对结合力（以注射剂量的百分比计算）高于青少年。使用[3H] CP55,940（F（10,99）= 140.1，P <0.0001）的体外放射自显影证实了这一发现。这种个体发育模式表明从青春期到成年期的过程中CB1R的增加，与这一时期进行修剪的大多数其他神经受体系统相反。

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