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Prevention and Treatment of Respiratory Consequences Induced by Sulfur Mustard in Iranian Casualties

机译:预防和治疗伊朗伤亡中芥末引起的呼吸道后果

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Background: About 100,000 Iranian have been exposed to chemical weapons during Iraq-Iran conflict (1980-88). After being spent of more than two decades, still about 30,000 of them are under follow-up treatment. The main aim of this study was to review various preventive and therapeutic methods for injured patients with sulfur mustard in different phases. Methods: For gathering information, we have used the electronic databases including Scopus, Medline, ISI, IranMedex, Irandoc sites. According to this search strategy, 104 published articles associated to respiratory problems and among them 50 articles related to prevention and treatment of respiratory problems were found and reviewed. Results: There is not any curative treatment for sulfur mustard induced lung injuries, but some valuable experienced measures for prevention and palliative treatments are available. Some useful measures in acute phase include: Symptomatic management, oxygen supplementation, tracheostomy in laryngospasm, use of moist air, respiratory physical therapy, mucolytic agents and bronchodilators. In the chronic phases, these measures include: Periodic clinical examinations, administration of inhaled corticosteroids alone or with long-acting beta 2 agonists, use of antioxidants, magnesium ions, long term oxygen supplement, therapeutic bronchoscopy, laser therapy, and use of respiratory tract stents. Conclusions: Most treatments are symptomatic but using preventive points immediately after exposure could improve following outcomes.
机译:背景:在伊拉克与伊朗的冲突期间(1980-88年),约有10万伊朗人暴露于化学武器中。在花费了二十多年之后,仍然有大约30,000接受了后续治疗。这项研究的主要目的是回顾针对不同阶段的硫芥子受伤患者的各种预防和治疗方法。方法:为了收集信息,我们使用了电子数据库,包括Scopus,Medline,ISI,IraneMedex,Irandoc网站。根据该检索策略,找到并审查了104篇与呼吸系统疾病有关的已发表文章,其中50篇与呼吸系统疾病的预防和治疗有关。结果:目前尚无治疗硫芥子气引起的肺损伤的治疗方法,但可以采取一些有价值的预防和姑息治疗措施。急性期的一些有用措施包括:对症处理,增氧,喉痉挛气管切开术,使用潮湿空气,呼吸道物理疗法,粘液溶解剂和支气管扩张剂。在慢性期,这些措施包括:定期临床检查,单独或与长效β2激动剂一起吸入皮质类固醇吸入,使用抗氧化剂,镁离子,长期供氧,支气管镜检查,激光治疗和使用呼吸道支架。结论:大多数治疗是对症治疗,但接触后立即使用预防措施可以改善预后。

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