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首页> 外文期刊>International Journal of Pharmaceutical Sciences Review and Research >Anticonvulsant Assessment of Alcoholic and Aqueous Extracts of Leaves of Shorea robusta
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Anticonvulsant Assessment of Alcoholic and Aqueous Extracts of Leaves of Shorea robusta

机译：浓郁浓郁浓郁的浓郁浓郁的浓郁浓郁

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The present study was undertaken to evaluate the CNS activity of different extracts of leaves of Shorea robusta. Swiss albino micewere subjected to dosages of 100, 300 & 500mg/kg each extract for the study for anticonvulsant action. The methanolic andaqueous extracts were evaluated using PTZ induced seizures (PTZ 100 mg/kg), picrotoxin induced seizures (picrotoxin 3.5 mg/kg),strychnine induced seizures (strychnine 4mg/kg), and MES (Maximum electroshock method, 75mA current). Diazepam andphenytoin were used as standard drug with the dose of 4 mg/kg and 25mg/kg respectively in all the experimental models. Thesignificance of final result was calculated by applying one way ANOVA followed by Dunneet’s t- Test and compared with the controlgroup. The software used for calculating the significance was Graph Pad (All values expressed as mean ± SEM; n=6 mice in eachgroup, significance values are *p<0.05 and ***p<0.001.) The methanol extracts showed significant anticonvulsant activity byincreasing the time of latency and reducing duration of extensor phase of seizure in MES and PTZ induced seizures. However,picrotoxin and strychnine induced seizure model shows little or no significant results. The ideal dose from the methanol extract was300 and 500 mg/kg.
机译：进行本研究以评价强壮的浓脂树的不同提取物的CNS活性。研究瑞士白化病小鼠的提取物剂量分别为100、300和500mg / kg，以研究其抗惊厥作用。使用PTZ诱发的癫痫发作（PTZ 100 mg / kg），苦味毒素诱发的癫痫发作（pictotoxin 3.5 mg / kg），司氏碱引起的癫痫发作（司氏碱4mg / kg）和MES​​（最大电击法，75mA电流）评估甲醇和水提取物。在所有实验模型中，地西p和苯妥英钠分别作为标准药物，剂量分别为4 mg / kg和25mg / kg。最终结果的意义是通过采用一种方差分析，Dunneet的t检验进行计算，并与对照组进行比较。用于计算显着性的软件为Graph Pad（所有值均表示为平均值±SEM;每组n = 6只小鼠，显着性值为* p <0.05和*** p <0.001。）甲醇提取物通过增加而显示出显着的抗惊厥活性在MES和PTZ诱发的癫痫发作中潜伏时间的延长和延长伸肌阶段的持续时间的减少。然而，猪毒素和士的宁诱导的癫痫发作模型显示很少或没有明显结果。甲醇提取物的理想剂量为300和500 mg / kg。

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