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首页> 外文期刊>International Journal of Research in Medical Sciences >The effect of induction chemotherapy followed by chemoradiotherapy in advanced head and neck cancer: a prospective study
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The effect of induction chemotherapy followed by chemoradiotherapy in advanced head and neck cancer: a prospective study

机译：诱导化疗后放化疗在晚期头颈癌中的作用：一项前瞻性研究

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Background: Objective of current study was to observe the local control, progression free survival and organ preservation for locally advanced head and neck cancer by using induction Chemotherapy followed by concurrent chemoradiotherapy. Methods: 102 patients enrolled in this study with stage III-IVB of head & neck cancer. Patients were assessed and treated by faculty of the department as per NCCN guidelines. Group A patients received three courses of cisplatin (100mg/m2) and paclitaxel (175mg/m2) at every 21 days interval followed by concurrent chemoradiothearpy with cisplatin 30mg/m2 on weekly basis while group B received only concurrent chemoradiothearpy. Radiotherapy consisted of total dose up to 66-70 Gy. by conventional fractionation schedule. Results: From August 2011 to July 2013, total 102 patients have completed 14 months of follow up after completing definitive treatment group A : 48 and group B: 54 patients. Response evaluation was done after one and half months of completion of chemoradiotherapy in both arms. Complete response rate was 60.42% and 38.88 % in study and control arm respectively while partial response was 72.92% and 55.56%. Most common grade III or IV toxicity was mucositis in group A and skin reaction in control arm. At a median follow-up 13 months the median progression free survival in group A was 11.5 months and 9 months in group B. Conclusion: Response to induction chemotherapy was useful as predictive factor for ultimate outcome and progression free survival. But our study shows statistically significant improvement in complete response rate in group A as compared to group B (p<0.05). Our induction chemotherapy with two-drug regimen followed by concurrent chemoradiotherapy was well tolerated with manageable toxicity and good locoregional control.
机译：背景：本研究的目的是通过诱导化疗和同期放化疗联合治疗局部晚期头颈癌的局部控制，无进展生存期和器官保存。方法：本研究纳入102例头颈癌III-IVB期的患者。根据NCCN指南，由系的教员对患者进行评估和治疗。 A组患者每隔21天接受3疗程的顺铂（100mg / m2）和紫杉醇（175mg / m2）治疗，随后每周并发顺铂联合顺铂30mg / m2，而B组仅接受并发顺铂。放疗的总剂量高达66-70 Gy。按常规分馏时间表进行。结果：从2011年8月至2013年7月，总共102例患者在完成明确的治疗组A：48名和B组：54名患者后完成了14个月的随访。两只手臂放化疗完成一个半月后，进行反应评估。研究组和对照组的完全缓解率分别为60.42％和38.88％，部分缓解率为72.92％和55.56％。最常见的III或IV级毒性是A组粘膜炎和对照组的皮肤反应。在中位随访13个月时，A组的中位无进展生存期为11.5个月，B组中的无进展生存期为9个月。结论：对诱导化疗的反应可用作最终结果和无进展生存期的预测因素。但我们的研究显示，与B组相比，A组的完全缓解率有统计学上的显着提高（p <0.05）。我们采用两药方案的诱导化疗，然后进行同步放化疗，具有良好的耐受性，可控制的毒性和良好的局部控制。

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