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首页> 外文期刊>American Journal of Medicine Studies >Effect of Anti-Thyroperoxidase on Thyroid Gland and Breast Tissue: A Comprehensive Review
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Effect of Anti-Thyroperoxidase on Thyroid Gland and Breast Tissue: A Comprehensive Review

机译：抗甲状腺过氧化物酶对甲状腺和乳腺组织的影响：综述

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Relationship between thyroid disease and breast tissue has long been debated as both the tissues have same embryological origin. Recent studies have implicated the possible role of thyroid dysfunction in the development and progression of breast related disorders. In view of increased prevalence of hypo and hyper thyroidism globally, there is a possibility of hormonal imbalance which may contribute to the initiation of tumor growth. Current literature has confirmed the role of sodium-iodide symporter (NIS) gene expression in breast cancers. Elevated anti-thyroperoxidase enzyme has been associated with increased risk of breast cancer. Activity of thyroid gland in post menopausal women, role of iodide levels and its relation to breast tissue and development of breast cancer needs extensive evaluation. In this comprehensive review we describe the role of NIS in thyroid gland functioning, thyroid hormone signaling mechanism.
机译：甲状腺疾病与乳房组织之间的关系长期以来一直受到争论，因为这两种组织具有相同的胚胎学起源。最近的研究暗示甲状腺功能障碍可能在乳腺相关疾病的发生和发展中发挥作用。鉴于全球甲状腺功能低下和甲状腺功能亢进的患病率增加，可能存在激素失衡的情况，这可能有助于引发肿瘤的生长。当前文献已经证实碘化钠同向转运蛋白（NIS）基因表达在乳腺癌中的作用。抗甲状腺素过氧化物酶升高与患乳腺癌的风险增加有关。绝经后妇女的甲状腺活性，碘化物水平的作用及其与乳腺组织的关系以及乳腺癌的发展需要广泛评估。在这项全面的综述中，我们描述了NIS在甲状腺功能，甲状腺激素信号传导机制中的作用。

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