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首页> 外文期刊>American Journal of Medicine Studies >Effect of Combination between Methotrexate and Histone Deacetylase Inhibitors on Transplantable Tumor Model
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Effect of Combination between Methotrexate and Histone Deacetylase Inhibitors on Transplantable Tumor Model

机译：甲氨蝶呤和组蛋白脱乙酰基酶抑制剂的组合对可移植肿瘤模型的影响

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Solid Ehrlich carcinoma is an undifferentiated tumor used in tumor studies. Methotrexate is an antimetabolite used in treatment of cancer, autoimmune diseases and induction of abortion. Valproic acid is used as anticonvulsant and is under investigation for treatment of cancer. The aim of this work was to study the effect of each of methotrexate and valproic acid alone and in combination on solid Ehrlich tumor in mice. Fifty albino mice were divided into five equal groups: Control untreated group, solid Ehrlich carcinoma, solid Ehrlich carcinoma + methotrexate, solid Ehrlich carcinoma + valproic acid, solid Ehrlich carcinoma + methotrexate + valproic acid. Tumor volume, tissue catalase, glutathione reductase, malondialdehyde, cholesterol and tumor necrosis factor-α were determined. A part of the tumor was examined for histopathological and immunohistochemical study. Methotrexate or valproic acid alone or in combination induced significant increase in tissue catalase and glutathione reductase with significant decrease in tumor volume, tissue malondialdehyde, cholesterol and tumor necrosis factor-α and alleviated the histopathological changes with significant increase in p53 expression and apoptotic index compared to solid Ehrlich carcinoma group. The combination of methotrexate and valproic acid has a better effect than each of methotrexate or valproic acid alone against solid Ehrlich tumor in mice.
机译：实体艾氏癌是用于肿瘤研究的未分化肿瘤。甲氨蝶呤是一种抗代谢药物，用于治疗癌症，自身免疫性疾病和人工流产。丙戊酸用作抗惊厥药，正在研究治疗癌症的方法。这项工作的目的是研究单独和联合使用甲氨蝶呤和丙戊酸对小鼠固体艾氏肿瘤的作用。将五十只白化病小鼠分成五个相等的组：对照组，未治疗组，实体埃希氏癌，实体埃希氏癌+甲氨蝶呤，实体埃希氏癌+丙戊酸，实体埃希氏癌+甲氨蝶呤+丙戊酸。测定肿瘤体积，组织过氧化氢酶，谷胱甘肽还原酶，丙二醛，胆固醇和肿瘤坏死因子-α。检查了肿瘤的一部分以进行组织病理学和免疫组织化学研究。与之相比，单独或联合使用甲氨蝶呤或丙戊酸引起组织过氧化氢酶和谷胱甘肽还原酶显着增加，肿瘤体积，组织丙二醛，胆固醇和肿瘤坏死因子-α显着降低，并且减轻了组织病理学变化，p53表达和凋亡指数显着增加。实体艾氏癌组。甲氨蝶呤和丙戊酸的组合比单独的甲氨蝶呤或丙戊酸对小鼠实体艾氏肿瘤的疗效更好。

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