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首页> 外文期刊>American Journal of Medicine Studies >Deletion Polymorphism of Glutathione S-transferases M1 and T1 genes in the Sudanese Population
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Deletion Polymorphism of Glutathione S-transferases M1 and T1 genes in the Sudanese Population

机译：苏丹人群谷胱甘肽S-转移酶M1和T1基因的缺失多态性

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Glutathione S-transferases (GSTs) play a major role in the detoxification of various compounds. Polymorphic variants in GST genes were reported for different populations. The main objective of this study was to determine the frequencies of GSTM1 and GSTT1 null genotypes in the Sudanese population. GST genotyping was carried out using multiplex PCR. Study population included 114 unrelated healthy Sudanese subjects. The results showed that the prevalence of GSTM1 and GSTT1 deletion homozygosity among Sudanese were 54.7% and 42.1%, respectively. There are no significant differences in allelic distribution of GSTM1 gene between the Sudanese and other ethnic groups except for sub-Saharan Africans. As regards the allelic distribution of GSTT1 genes, the Sudanese population is similar to sub-Saharan Africans but significantly different from Europeans. Combined analysis of both genes revealed that 24.6% of Sudanese harbor the deleted genotype of both genes and it is the highest reported so far for an Arab and African population. This is the first study that addresses deletion polymorphism of GST genes in Sudanese. We provide a reference database of allelic frequencies of the GSTM1 and GSTT1 genotypes among Sudanese.
机译：谷胱甘肽S-转移酶（GST）在各种化合物的解毒中起主要作用。据报道，不同人群的GST基因多态性变异。这项研究的主要目的是确定苏丹人群中GSTM1和GSTT1无效基因型的频率。使用多重PCR进行GST基因分型。研究人群包括114名无关的健康苏丹受试者。结果表明，苏丹人中GSTM1和GSTT1缺失纯合子的发生率分别为54.7％和42.1％。除撒哈拉以南非洲人外，苏丹人与其他种族之间的GSTM1基因等位基因分布没有显着差异。关于GSTT1基因的等位基因分布，苏丹人口与撒哈拉以南非洲人相似，但与欧洲人明显不同。对这两个基因的综合分析显示，苏丹人中有24.6％的人都具有两个基因的缺失基因型，这是迄今为止阿拉伯和非洲人口中报道最高的基因型。这是第一个研究苏丹语中GST基因缺失多态性的研究。我们提供了苏丹人之间GSTM1和GSTT1基因型等位基因频率的参考数据库。

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