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首页> 外文期刊>International Journal of Science and Qualitative Analysis >The Investigation of Zinc-Dependent Enzymes in Pregnant Women and their Correlation to Zinc Deficiency
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The Investigation of Zinc-Dependent Enzymes in Pregnant Women and their Correlation to Zinc Deficiency

机译：孕妇锌依赖酶的调查及其与锌缺乏的关系

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Zinc is present throughout the body in low concentration, but in most tissues. It performs multiple critical functions and must be supplied at adequate levels consistently or deficiency states will result, from mild to severe. Zinc deficiency is insufficient zinc to meet the needs of biological organisms. Due to its essentiality, a lack of this trace element leads to far more severe and widespread problems. Enzymes are large biological molecules responsible for the thousands of chemical inter-conversions that sustain life. Enzymes are usually very specific as to which reactions they catalyze and the substrates that are involved in these reactions. Complementary shape, charge and hydrophilic/ hydrophobic characteristics of enzymes and substrates are responsible for this specificity. Specimens were collected at the University Hospital of Obstetrics and Gynecology “Queen Geraldine” in Tirana, Albania during a period of time from year 2011 to 2013. We took into consideration 500 cases of pregnant women from first to third trimester of pregnancy. Serum zinc was measured by using Photometry (End-Point) method, whereas zinc enzymes such as Alkaline Phosphatase, Amylase, Gamma-glutamyl Transpeptidase, Lactate Dehydrogenase, Creatine Kinase, Aspartate Amino-Transferase, Glutamic Pyruvic Transaminase, Lipase measured with the corresponding methods: Beckman Synchron LX20, Colorimetric ab102523 kit, GenWays GGT kit, nonradioactive colorimetric LDH kit, Max Discovery, Colorimetric kit, Abcam kit and Biovision kit. From 500 cases taken into consideration, 190 pregnant women (38%) had normal zinc values (70 – 120 mcg/dl) 58 pregnant women (11.6%) had zinc levels between 60 – 69.9 mcg/dl, patients which were identified as pregnant women with zinc deficiency, as a consequence of oral contraceptive use; 252 pregnant women (50.4%) with zinc values 60 mcg/dl, identified as patients with zinc deficiency, a result of malnutrition and also urinary elimination of digestive liquids; 56 pregnant women (11.2%) with zinc values 30 mcg/dl, identified as patient with definite deficiency as a result of different diseases like acrodermatitis enteropathica ect. According to these results, there was a positive correlation between zinc and enzymes such as ALP, CK and LDH in pregnant women suffering from hypertension, whereas a negative correlation of zinc to enzymes such GGT, AST and GPT in cases with anemia. Zinc prophylactic treatment is important before and during pregnancy. Without a proper nutritional requirement the person falls in the state of zinc deficiency.
机译：锌以低浓度存在于全身，但存在于大多数组织中。它执行多种关键功能，并且必须始终提供足够的水平，否则从轻度到严重都会导致缺乏状态。缺锌不足以满足生物的需求。由于其必要性，缺少这种微量元素会导致更为严重和广泛的问题。酶是大型生物分子，负责维持生命的数千种化学相互转化。酶通常对催化哪些反应以及这些反应涉及的底物具有非常高的特异性。酶和底物的互补形状，电荷和亲水/疏水特性决定了这种特异性。在2011年至2013年的一段时间内，从阿尔巴尼亚地拉那的妇产科大学医院“ Queen Geraldine”收集了标本。我们考虑了从怀孕的第一期到第三期的500例孕妇。血清锌的测定采用光度法（终点法），而锌酶（如碱性磷酸酶，淀粉酶，γ-谷氨酰转肽酶，乳酸脱氢酶，肌酸激酶，天冬氨酸氨基转移酶，谷氨酸丙酮酸转氨酶，脂肪酶）则采用相应的方法进行测定。 ：Beckman Synchron LX20，比色ab102523试剂盒，GenWays GGT试剂盒，非放射性比色LDH试剂盒，Max Discovery，比色试剂盒，Abcam试剂盒和Biovision试剂盒。在考虑的500例病例中，有190名孕妇（38％）的锌含量正常（70 – 120 mcg / dl）。58名孕妇（11.6％）的锌含量在60 – 69.9 mcg / dl之间，这些患者被确定为孕妇由于口服避孕药而缺锌的妇女;锌含量<60 mcg / dl的252名孕妇（50.4％）被确定为锌缺乏症的患者，其原因是营养不良和尿液中消化液的清除;锌值<30 mcg / dl的56名孕妇（占11.2％）被确定为由于各种疾病（如肠炎性肠病）而明显缺乏。根据这些结果，在患有高血压的孕妇中，锌与酶（如ALP，CK和LDH）之间呈正相关，而在贫血患者中锌与酶（如GGT，AST和GPT）呈负相关。锌的预防治疗在怀孕前和怀孕期间很重要。如果没有适当的营养要求，则该人会陷入缺锌状态。

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