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Introducing the Forensic Research/Reference on Genetics knowledge base, FROG-kb

机译：介绍遗传学的法医学研究/参考知识库FROG-kb

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Background Online tools and databases based on multi-allelic short tandem repeat polymorphisms (STRPs) are actively used in forensic teaching, research, and investigations. The Fst value of each CODIS marker tends to be low across the populations of the world and most populations typically have all the common STRP alleles present diminishing the ability of these systems to discriminate ethnicity. Recently, considerable research is being conducted on single nucleotide polymorphisms (SNPs) to be considered for human identification and description. However, online tools and databases that can be used for forensic research and investigation are limited. Methods The back end DBMS (Database Management System) for FROG-kb is Oracle version 10. The front end is implemented with specific code using technologies such as Java, Java Servlet, JSP, JQuery, and GoogleCharts. Results We present an open access web application, FROG-kb (Forensic Research/Reference on Genetics-knowledge base, http://frog.med.yale.edu webcite ), that is useful for teaching and research relevant to forensics and can serve as a tool facilitating forensic practice. The underlying data for FROG-kb are provided by the already extensively used and referenced ALlele FREquency Database, ALFRED ( http://alfred.med.yale.edu webcite ). In addition to displaying data in an organized manner, computational tools that use the underlying allele frequencies with user-provided data are implemented in FROG-kb. These tools are organized by the different published SNP/marker panels available. This web tool currently has implemented general functions possible for two types of SNP panels, individual identification and ancestry inference, and a prediction function specific to a phenotype informative panel for eye color. Conclusion The current online version of FROG-kb already provides new and useful functionality. We expect FROG-kb to grow and expand in capabilities and welcome input from the forensic community in identifying datasets and functionalities that will be most helpful and useful. Thus, the structure and functionality of FROG-kb will be revised in an ongoing process of improvement. This paper describes the state as of early June 2012.
机译：背景技术基于多等位基因短串联重复序列多态性（STRP）的在线工具和数据库被积极地用于法医教学，研究和调查。每个CODIS标记的Fst值在世界各地的人群中往往较低，并且大多数人群通常都具有所有常见的STRP等位基因，从而削弱了这些系统区分种族的能力。最近，正在对单核苷酸多态性（SNP）进行大量研究，以用于人类识别和描述。但是，可用于法医研究和调查的在线工具和数据库是有限的。方法FROG-kb的后端DBMS（数据库管理系统）是Oracle版本10。前端使用Java，Java Servlet，JSP，JQuery和GoogleCharts等技术通过特定代码实现。结果我们提出了一个开放访问的Web应用程序FROG-kb（法医研究/遗传学参考知识库，http：//frog.med.yale.edu网站），该应用程序可用于与法医学有关的教学和研究，并且可以为您服务作为促进司法实践的工具。 FROG-kb的基础数据由已经广泛使用和引用的ALlele频率数据库ALFRED（http://alfred.med.yale.edu webcite）提供。除了以有组织的方式显示数据之外，还可以在FROG-kb中实现将基础等位基因频率与用户提供的数据结合使用的计算工具。这些工具由可用的不同已发布的SNP /标记面板组织。该网络工具当前已实现了两种类型的SNP面板可能的常规功能，即个体识别和祖先推断，以及针对眼睛颜色的表型信息面板特有的预测功能。结束语当前的FROG-kb在线版本已经提供了新的有用功能。我们希望FROG-kb的功能会不断增长和扩展，并欢迎法医界在确定最有用和有用的数据集和功能方面的投入。因此，将在正在进行的改进过程中修改FROG-kb的结构和功能。本文介绍了截至2012年6月上旬的状态。

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