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首页> 外文期刊>Iranian Journal Of Allergy, Asthma and Immunology >Effect of age and eosinophil number on fractional exhaled nitric oxide level in non-asthmatic children in shanghai.
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Effect of age and eosinophil number on fractional exhaled nitric oxide level in non-asthmatic children in shanghai.

机译：年龄和嗜酸性粒细胞数量对上海非哮喘儿童呼出气一氧化氮水平的影响。

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摘要

This study aimed to identify the relationship between fractional exhaled nitric oxide (FeNO) level and potential factors in non-asthmatic children from Shanghai, China. From March to April 2012, the school-aged children fulfilling the inclusion criteria were recruited. The FeNO levels of non-asthmatic children were detected by the Nano Coulomb nitric oxide analyzer. Questionnaires were recorded, including personal data, family illness history and daily habits. In addition, not only the number of leukocytes and eosinophils but also the level of hemoglobin in peripheral blood, were measured via the automated blood cell analyzer. All data were statistically analyzed with SPSS version 17.0 software and the correlation of these potential factors with FeNO level was calculated via Kendall's rank correlation. A total of 132 healthy children (aging 6-13 years) were enrolled in Minhang District, Shanghai, China. The mean value of FeNO level was 15.05 ppb. The correlation analyses revealed that age (R=0.190, p=0.029) and eosinophil number (R=0.575, p=0.000) were significantly and positively correlated with FeNO levels. The FeNO levels of individuals aged 10-13 years was significantly higher than those of the individuals aged 6-9 years (22.65 ± 18.82 ppb vs. 15.28 ± 9.78 ppb, p<0.05). However, other potential factors were not significantly correlated with FeNO level. The FeNO levels in healthy school-aged children may reflect airway eosinophilic inflammation levels, and was affected by eosinophil count and age significantly.
机译：本研究旨在确定中国上海非哮喘儿童呼出气一氧化氮（FeNO）水平与潜在因素之间的关系。 2012年3月至2012年4月，招募了符合纳入标准的学龄儿童。纳米库仑一氧化氮分析仪检测非哮喘儿童的FeNO水平。记录问卷，包括个人数据，家庭疾病史和日常习惯。另外，通过自动血细胞分析仪不仅测量了白细胞和嗜酸性粒细胞的数目，而且还测量了外周血中的血红蛋白水平。使用SPSS 17.0版软件对所有数据进行统计分析，并通过Kendall等级相关性计算这些潜在因素与FeNO水平的相关性。中国上海市闵行区共有132名健康儿童（年龄在6-13岁之间）参加。 FeNO含量平均值为15.05 ppb。相关分析表明，年龄（R = 0.190，p = 0.029）和嗜酸性粒细胞数（R = 0.575，p = 0.000）与FeNO水平呈显着正相关。 10-13岁个体的FeNO水平显着高于6-9岁个体（22.65±18.82 ppb vs. 15.28±9.78 ppb，p <0.05）。但是，其他潜在因素与FeNO水平没有显着相关。健康学龄儿童中的FeNO水平可能反映出气道嗜酸性粒细胞炎症水平，并受到嗜酸性粒细胞数量和年龄的显着影响。

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