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首页> 外文期刊>Iranian journal of public health. >Safety of Inactivated Influenza Vaccine in Patients with Egg Allergy in Kurdistan Province, Iran
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Safety of Inactivated Influenza Vaccine in Patients with Egg Allergy in Kurdistan Province, Iran

机译：伊朗库尔德斯坦省鸡蛋过敏患者中灭活流感疫苗的安全性

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Background: Most influenza vaccines are grown in embryonated eggs and residual egg proteins can cause allergic reactions in patients with egg allergy. The aim of the present study was to determine the safety of inactivated influenza vaccine in patients with egg allergy in Kurdistan Province, Iran. Methods: This case-control study was done on 876 patients referred to Kurdistan Asthma and Allergy Clinic, Sanandaj, Iran; 635 patients with egg allergy (cases) and 241 patients without egg allergy (controls) from 2012 to 2016. All of the patients were injected seasonal influenza vaccine. Side effects including anaphylactic shock, local reaction, vomiting, coughing, sneezing, wheezing, low blood pressure, redness and itching in the eyes, abdominal pain, dyspnea, oral/facial angioedema, swollen and itching of throat were checked by an allergist within 30 min after vaccination, and followed up to 24 h. Demographic and vaccination data were entered into the SPSS software and analyzed. Results: Out of 876 patients, 460 (52.5%) were male. Patients' ages ranged from 6 months to 80 yr (mean 13.38 ± 15.22 SD). Overall, 63 patients with egg allergy had local reactions to vaccine. Difference of local reactions between case and control groups was statistically significant (P=0.001). No anaphylactic reactions were seen after vaccination. Conclusion: Although the risk of anaphylactic reactions to influenza vaccine in patients with egg allergy was rare, the vaccine should be administered by an allergist with precaution. The results of present study can be a confirmation of the existing evidences to prevent acute complications to influenza vaccine.
机译：背景：大多数流感疫苗都是在有胚卵中生长的，残留的卵蛋白会导致鸡蛋过敏的患者产生过敏反应。本研究旨在确定灭活的流感疫苗对伊朗库尔德斯坦省鸡蛋过敏患者的安全性。方法：本病例对照研究是针对876名转诊至伊朗Sanandaj的库尔德斯坦哮喘和过敏诊所的患者进行的;从2012年到2016年，有635例鸡蛋过敏患者（病例）和241例鸡蛋过敏患者（对照组）。所有患者均注射了季节性流感疫苗。 30岁以内的过敏症专科医师检查了过敏反应，局部反应，呕吐，咳嗽，打喷嚏，喘息，血压低，眼睛发红和瘙痒，腹痛，呼吸困难，口腔/面部血管性水肿，喉咙肿胀和瘙痒等副作用。在接种疫苗后的5分钟内，并进行长达24小时的随访。将人口统计数据和疫苗接种数据输入SPSS软件并进行分析。结果：876名患者中，460名（52.5％）是男性。患者的年龄为6个月至80岁（平均13.38±15.22 SD）。总体而言，63例鸡蛋过敏患者对疫苗有局部反应。病例组和对照组之间的局部反应差异具有统计学意义（P = 0.001）。疫苗接种后未见过敏反应。结论：尽管鸡蛋过敏患者对流感疫苗产生过敏反应的风险极少，但应由过敏者慎用该疫苗。本研究的结果可以证实现有的预防流感疫苗急性并发症的证据。

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