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首页> 外文期刊>Italian Journal of Medicine >Sitagliptin versus saxagliptin in decompensated type 2 diabetes mellitus patients
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Sitagliptin versus saxagliptin in decompensated type 2 diabetes mellitus patients

机译：西格列汀与沙格列汀治疗失代偿的2型糖尿病患者

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Sitagliptin and saxagliptin are oral hypoglycemic agents inhibitors of DPP-4, indicated in the treatment of type 2 diabetes mellitus in combination with metformin, in patients who have not achieved adequate glycemic control. In our study we enrolled 128 decompensated type 2 diabetes patients while on metformin maximum dosage. At time 0’ we have detected, body mass index (BMI), total cholesterol, high- and low-density lipoproteins (HDL and LDL), triglycerides, transaminases and pancreatic amylase; patients were randomized to receive sitagliptin or saxagliptin; follow-up was performed after 4 months with the revaluation of the same variables and adverse events. In both sitagliptin and saxagliptin groups we observed a significant reduction in fasting glucose, glycated hemoglobin, weighing, BMI, triglycerides, while the reduction in total cholesterol, LDL cholesterol did not reach statistical significance. There was no suspension of therapy, adverse events appeared minor and temporary. In conclusion, our observations highlight the almost identical efficacy of sitagliptin and saxagliptin. These data reinforce even more the idea that we should think about this class of drugs as the next step in patients failing therapy with metformin.
机译：西他列汀和沙格列汀是DPP-4的口服降糖药抑制剂，在尚未实现充分血糖控制的患者中联合2型糖尿病与二甲双胍一起治疗。在我们的研究中，我们招募了128位失代偿的2型糖尿病患者，同时服用二甲双胍的最大剂量。在时间0'，我们检测到了体重指数（BMI），总胆固醇，高密度和低密度脂蛋白（HDL和LDL），甘油三酸酯，转氨酶和胰淀粉酶;患者随机接受西他列汀或沙格列汀治疗; 4个月后进行随访，重新评估相同的变量和不良事件。在西他列汀和沙格列汀组中，我们观察到空腹血糖，糖化血红蛋白，体重，BMI，甘油三酯的显着降低，而总胆固醇，LDL胆固醇的降低没有统计学意义。没有暂停治疗，不良事件出现轻微和暂时的。总之，我们的观察结果突出了西他列汀和沙格列汀的几乎相同的功效。这些数据更加坚定了我们应该考虑将这类药物作为二甲双胍治疗失败的患者下一步的想法。

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