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首页> 外文期刊>Iranian journal of medical hypotheses and ideas. >Caveola is a key vehicle for paraquat uptake into lung
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Caveola is a key vehicle for paraquat uptake into lung

机译：Caveola是百草枯摄入肺的关键工具

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摘要

Paraquat dichloride (PQ) is an effective and widely used herbicide for eliminating weeds. However, once being accidentally or voluntarily ingested, PQ-poisoned patients have the very high incidence of adult respiratory distress syndrome because lung can actively absorb PQ. Since the 1970s, evidence suggested that polyamine competitively inhibited uptake of PQ into lung tissue; therefore, polyamine transport system has been regarded as an important vehicle for PQ uptake into lung. However, so far, we cannot clone or detect the polyamine transport system in mammalian animal. Recent evidence from diverse sources has suggested that caveola may be an important vehicle for polyamine absorption into lung. Herein we hypothesise that caveola is a key vehicle for PQ uptake in lung and hence blocking the expression of caveola may serve as new targets for treatment of PQ poisoning.
机译：百草枯二氯化物（PQ）是一种有效且广泛使用的除草剂，可消除杂草。但是，一旦意外或自愿摄入PQ中毒的患者，由于肺部可以主动吸收PQ，因此成人呼吸窘迫综合征的发生率很高。自1970年代以来，证据表明多胺竞争性地抑制了PQ对肺组织的吸收。因此，多胺转运系统已被认为是肺部PQ摄取的重要媒介。但是，到目前为止，我们还不能克隆或检测哺乳动物中的多胺转运系统。来自不同来源的最新证据表明，海绵体可能是多胺被肺吸收的重要媒介。本文中我们假设小窝是肺中PQ摄取的关键媒介，因此阻断小窝的表达可能成为治疗PQ中毒的新靶标。

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