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首页> 外文期刊>Iranian Journal of Microbiology >The effect of a single-strain probiotic administration in the treatment of thermal burns patients
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The effect of a single-strain probiotic administration in the treatment of thermal burns patients

机译：单株益生菌给药对热烧伤患者的治疗作用

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Background and Objectives: Between 2007 and 2011, the mortality rate for burns patients at Dr. Soetomo General Hospital, Surabaya, Indonesia was 14.1% and 60% were suspected to be sepsis-related. Immunosuppression, gut barrier disruption, and intestinal hypomotility cause bacterial and bacterial product translocation. Probiotics improve the intestinal microbiome and eventually reduce bacterial translocation, and an increased secretory immunoglobulin A (SIgA) secretion post-administration of a multi-species probiotic has been observed. We aimed to determine whether a single-strain probiotic administration could show strengthened intestinal immunity, through an increase in SIgA levels, as with multi-strain probiotics. Materials and Methods: Sixteen burns patients from our hospital Burns Centre were randomized into three treatment groups, and the patients were administered either a placebo, a Lactobacillus reuteri protectis probiotic, or a Bifidobacterium infantis 35624 probiotic for 14 consecutive days. The SIgA levels were analyzed using ELISA pre- and post-treatment. Results: The post-treatment SIgA levels in the placebo, Lactobacillus reuteri protectis probiotic, and Bifidobacterium infantis 35624 probiotic groups were 222.56±74.22 mg/dL, 223.92±68.89 mg/dL, and 332.38±64.27 mg/dL, respectively. Decreased SIgA levels were observed in the placebo (7.19±15.87) and in the Lactobacillus reuteri protectis probiotic (1.9920±14.76) groups, whereas an increase was seen in the SIgA level in the Bifidobacterium infantis 35624 probiotic group (58.26±77.41). Conclusion: The Bifidobacterium infantis 35624 single-strain probiotic is generally superior to Lactobacillus reuteri protectis in altering intestinal immunity; however, this finding was not statistically significant. A multi-strain probiotic supplement is recommended for burns patients.
机译：背景与目的：2007年至2011年，印度尼西亚泗水Soetomo总医院烧伤患者的死亡率为14.1％，怀疑60％与脓毒症有关。免疫抑制，肠屏障破坏和肠动力不足会引起细菌和细菌产物移位。益生菌改善肠道微生物组并最终减少细菌易位，并且已观察到多种物种益生菌给药后分泌的免疫球蛋白A（SIgA）分泌增加。我们旨在确定单菌株益生菌施用是否可以像多菌株益生菌一样通过提高SIgA水平来显示增强的肠道免疫力。材料与方法：将我院烧伤中心的16例烧伤患者随机分为3个治疗组，连续14天给予安慰剂，罗伊氏乳杆菌保护性益生菌或婴儿双歧杆菌35624益生菌。使用ELISA预处理和后处理分析SIgA水平。结果：安慰剂，罗伊氏乳酸杆菌益生菌和婴儿双歧杆菌35624益生菌组的治疗后SIgA水平分别为222.56±74.22 mg / dL，223.92±68.89 mg / dL和332.38±64.27 mg / dL。安慰剂组（7.19±15.87）和罗伊氏乳杆菌益生菌（1.9920±14.76）组的SIgA水平降低，而婴儿双歧杆菌35624益生菌组的SIgA水平升高（58.26±77.41）。结论：婴儿双歧杆菌35624单菌株益生菌在改变肠道免疫方面通常优于罗伊氏乳杆菌。但是，这一发现在统计上并不显着。建议烧伤患者使用多菌株益生菌补充剂。

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