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首页> 外文期刊>EBioMedicine >Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection
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Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection

机译：静脉免疫球蛋白可预防严重的大流行性流感感染

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Abstract Influenza is a highly contagious, acute, febrile respiratory infection that can have fatal consequences particularly in individuals with chronic illnesses. Sporadic reports suggest that intravenous immunoglobulin (IVIg) may be efficacious in the influenza setting. We investigated the potential of human {IVIg} to ameliorate influenza infection in ferrets exposed to either the pandemic H1N1/09 virus (pH1N1) or highly pathogenic avian influenza (H5N1). {IVIg} administered at the time of influenza virus exposure led to a significant reduction in lung viral load following pH1N1 challenge. In the lethal {H5N1} model, the majority of animals given {IVIg} survived challenge in a dose dependent manner. Protection was also afforded by purified F(ab′)2 but not Fc fragments derived from IVIg, supporting a specific antibody-mediated mechanism of protection. We conclude that pre-pandemic {IVIg} can modulate serious influenza infection-associated mortality and morbidity. {IVIg} could be useful prophylactically in the event of a pandemic to protect vulnerable population groups and in the critical care setting as a first stage intervention.
机译：摘要流行性感冒是一种高度传染性，急性，高热的呼吸道感染，特别是在患有慢性疾病的个体中，可能造成致命的后果。零星的报道表明静脉注射免疫球蛋白（IVIg）在流感环境中可能有效。我们研究了人类{IVIg}改善大流行H1N1 / 09病毒（pH1N1）或高致病性禽流感（H5N1）暴露的雪貂中流感感染的潜力。在暴露于流感病毒时施用的{IVIg}导致pH1N1攻击后肺病毒载量显着降低。在致命的{H5N1}模型中，大多数接受{IVIg}治疗的动物以剂量依赖性方式存活于攻击中。还通过纯化的F（ab'）2提供了保护，但不提供衍生自IVIg的Fc片段，从而支持了特异性抗体介导的保护机制。我们得出的结论是，大流行前{IVIg}可以调节严重的流感感染相关的死亡率和发病率。 {IVIg}可能在大流行时起到预防作用，以保护弱势人群和在重症监护环境中作为第一阶段干预措施。

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